Monic Acid A (CAS 66262-68-8)
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Monic Acid A is a naturally occurring antibiotic compound produced by certain strains of the bacterium Pseudomonas fluorescens. It is the precursor molecule to the more widely known mupirocin, a derivative with potent antibacterial properties. While Monic Acid A itself holds a foundational role in biochemical research, its primary significance lies in its unique mode of action at the molecular level, specifically targeting the isoleucyl-tRNA synthetase in bacteria. This action interferes with protein synthesis by preventing the proper loading of isoleucine onto its corresponding tRNA, a critical step in the translation process. As a result, Monic Acid A serves as a key subject of study in the investigation of bacterial resistance mechanisms and the development of novel antibiotic strategies.
Monic Acid A (CAS 66262-68-8) References
- The role of monic acid A in pseudomonic acid A biosynthesis in Pseudomonas fluorescens. | Mantle, PG. and Macgeorge, KM. 1990. Appl Microbiol Biotechnol. 33: 709-11. PMID: 1367487
- HPLC/MS/MS methodology for sensitive quantitation of monic acid A, the metabolic product of the antibiotic mupirocin. | Haidar, EA., et al. 2011. Biomarkers. 16: 422-5. PMID: 21595607
- Synthesis and activity of nonhydrolyzable pseudomonic acid analogues. | Klein, LL., et al. 1989. J Med Chem. 32: 151-60. PMID: 2491891
- Antimycoplasmal activities of the pseudomonic acids and structure-activity relationships of monic acid A derivatives. | Banks, RM., et al. 1988. J Antibiot (Tokyo). 41: 609-13. PMID: 3133344
- Chemical Fingerprinting and Biological Evaluation of the Endemic Chilean Fruit Greigia sphacelata (Ruiz and Pav.) Regel (Bromeliaceae) by UHPLC-PDA-Orbitrap-Mass Spectrometry. | Barrientos, RE., et al. 2020. Molecules. 25: PMID: 32824604
- Multiplex Hybrid Antigen-Capture LC-MRM Quantification in Sera and Nasal Lining Fluid of AZD7442, a SARS-CoV-2-Targeting Antibody Combination. | Mu, R., et al. 2022. Anal Chem. 94: 14835-14845. PMID: 36269894
- Antibacterial activity of mupirocin (pseudomonic acid), a new antibiotic for topical use. | Sutherland, R., et al. 1985. Antimicrob Agents Chemother. 27: 495-8. PMID: 3923922
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Monic Acid A, 5 mg | sc-484873 | 5 mg | $490.00 |