Molecular structure of Monazomycin, CAS Number: 11006-31-8
Monazomycin (CAS 11006-31-8)
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Alternate Names:
Takacidin
Application:
Monazomycin is a macrocyclic polyol lactone antibiotic isolated from Streptoverticilium
CAS Number:
11006-31-8
Molecular Weight:
1364.81
Molecular Formula:
C72H133NO22
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Monazomycin is a macrocylic polyol lactone isolated from several species of Streptoverticillium. It is active against Gram positive bacteria with weak Gram negative activity. In solution, monazomycin exists as hydrophilic clusters which, when adsorbed onto a lipid bilayer, can induce channel formation. It is an important bioprobe for understanding membrane channels.
Monazomycin (CAS 11006-31-8) References
- Kinetics of channel formation in bilayer lipid membranes (BLMs) and tethered BLMs: monazomycin and melittin. | Becucci, L. and Guidelli, R. 2007. Langmuir. 23: 5601-8. PMID: 17419655
- Monazomycin B, a new macrolide antibiotic of the monazomycin family. | Kuo, MS., et al. 1990. J Antibiot (Tokyo). 43: 438-40. PMID: 2351615
- Quadoctomycin, a 48-membered macrolide antibiotic from Streptomyces sp. MM168-141F8. | Sawa, R., et al. 2017. J Antibiot (Tokyo).. PMID: 29138481
- Temperature-Controlled Assembly and Characterization of a Droplet Interface Bilayer. | Ringley, JD. and Sarles, SA. 2021. J Vis Exp.. PMID: 33938884
- Bacterial marginolactones trigger formation of algal gloeocapsoids, protective aggregates on the verge of multicellularity. | Krespach, MKC., et al. 2021. Proc Natl Acad Sci U S A. 118: PMID: 34740967
- The Exploration of Microbial Natural Products and Metabolic Interaction Guided by Mass Spectrometry Imaging. | Li, H. and Li, Z. 2022. Bioengineering (Basel). 9: PMID: 36421108
- Voltage-dependent conductance induced in thin lipid membranes by monazomycin. | Muller, RU. and Finkelstein, A. 1972. J Gen Physiol. 60: 263-84. PMID: 5055789
- LL-A491, a monazomycin-like antibiotic. | Mitscher, LA., et al. 1967. Appl Microbiol. 15: 1002-5. PMID: 6077405
- Monazomycin-induced single channels. I. Characterization of the elementary conductance events. | Andersen, OS. and Muller, RU. 1982. J Gen Physiol. 80: 403-26. PMID: 6292330
- Identification of takacidin and antibiotic U-0142 with monazomycin and comparison of taxonomic properties of their producing organisms. | Nakayama, H., et al. 1983. J Antibiot (Tokyo). 36: 318-20. PMID: 6833152
- The monazomycin probe as detector of the interaction of charged lipid vesicles, polypeptides, proteins, and divalent cations with planar bilayer lipid membranes. | Cohen, JA. and Moronne, MM. 1978. Biochem Biophys Res Commun. 83: 1275-83. PMID: 697860
- The kinetics of monazomycin-induced voltage-dependent conductance. I. Proof of the validity of an empirical rate equation. | Muller, RU., et al. 1981. J Gen Physiol. 78: 171-200. PMID: 7276907
- The kinetics of monazomycin-induced voltage-dependent conductance. II. Theory and a demonstration of a form of memory. | Muller, RU. and Peskin, CS. 1981. J Gen Physiol. 78: 201-29. PMID: 7276908
- Inactivation of monazomycin-induced voltage-dependent conductance in thin lipid membranes. II. Inactivation produced by monazomycin transport through the membrane. | Heyer, RJ., et al. 1976. J Gen Physiol. 67: 731-48. PMID: 932673
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Monazomycin, 1 mg | sc-391676 | 1 mg | $330.00 | |||
Monazomycin, 5 mg | sc-391676A | 5 mg | $1100.00 |