MOLT-4 Cell Lysate: sc-2233

MOLT-4 cell lysate is derived from the MOLT-4 cell line, which originates from a human acute lymphoblastic leukemia (ALL) patient. This lysate is extensively used in research to study the molecular mechanisms of leukemia, particularly T-cell leukemia. MOLT-4 cells are characterized by their T-lymphoblast morphology and are utilized to investigate signaling pathways involved in cell proliferation, apoptosis, and differentiation. Researchers employ MOLT-4 cell lysate to analyze key signaling pathways such as the PI3K/Akt, MAPK/ERK, and JAK/STAT pathways, which are critical for regulating cell growth and survival. This lysate facilitates the study of protein expression, post-translational modifications, and interactions between signaling molecules that drive these pathways. Additionally, it is used to examine the effects of various chemical modulators on these signaling pathways, providing insights into the regulatory mechanisms of leukemia cell behavior and response to external stimuli. Recent studies have leveraged MOLT-4 cell lysate for proteomic and genomic analyses to identify novel biomarkers and signaling networks involved in leukemia progression. By offering detailed insights into the molecular and cellular mechanisms of leukemia, MOLT-4 cell lysate remains a vital resource for advancing research in oncology and understanding the complexities of cancer signaling.

MOLT-4 Cell Lysate References:

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2. Heat shock cognate protein 70 is a cell fusion-enhancing factor but not an entry factor for human T-cell lymphotropic virus type I.  |  Fang, D., et al. 1999. Biochem Biophys Res Commun. 261: 357-63. PMID: 10425190
3. Cleavage and phosphorylation of XRCC4 protein induced by X-irradiation.  |  Matsumoto, Y., et al. 2000. FEBS Lett. 478: 67-71. PMID: 10922471
4. p41 as a possible marker for cell death is generated by caspase cleavage of p42/SETbeta in irradiated MOLT-4 cells.  |  Morita, A., et al. 2000. Biochem Biophys Res Commun. 278: 627-32. PMID: 11095960
5. EWI-2 modulates lymphocyte integrin alpha4beta1 functions.  |  Kolesnikova, TV., et al. 2004. Blood. 103: 3013-9. PMID: 15070678
6. Delineation of three subsets of class I human T antigens (HTA) on Molt-4 cells: serologic and regulatory relationship to HLA class I antigens.  |  Kahn-Perles, B., et al. 1985. J Immunol. 134: 1759-65. PMID: 2578520
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10. A monoclonal antibody recognizing a human thymus leukemia-like antigen associated with beta 2-microglobulin.  |  Knowles, RW. and Bodmer, WF. 1982. Eur J Immunol. 12: 676-81. PMID: 6754387
11. JL1, a novel differentiation antigen of human cortical thymocyte.  |  Park, SH., et al. 1993. J Exp Med. 178: 1447-51. PMID: 8376947
12. Trypsin-sensitive and -resistant components in human T-cell membranes required for syncytium formation by human T-cell lymphotropic virus type 1-bearing cells.  |  Sagara, Y., et al. 1997. J Virol. 71: 601-7. PMID: 8985389
13. 71-kilodalton heat shock cognate protein acts as a cellular receptor for syncytium formation induced by human T-cell lymphotropic virus type 1.  |  Sagara, Y., et al. 1998. J Virol. 72: 535-41. PMID: 9420256