Mofegiline hydrochloride (CAS 120635-25-8)
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Mofegiline hydrochloride (MDL-72,974) is a selective, irreversible inhibitor of monoamine oxidase B (MAO-B) and amine oxidase, copper containing 3 (AOC3) or vascular adhesion protein 1 (VAP-1), also known as semicarbazide-sensitive amine oxidase (SSAO). Mofegiline hydrochloride demonstrates a time dependent irreversible inhibition of SSAO. In rat studies, Mofegiline hydrochloride showed preferential inhibition of brain MAO-B with ED50 values of 8 and 0.18 mg/kg p.o. for the A and B forms, respectively. In anaesthetized rats, Mofegiline hydrochloride did not significantly potentiate tyramine effects on the cardiovascular system. Mofegiline hydrochloride was studied and extensively researched as a potential treatment of Parkinson′s disease and Alzheimer′s disease, but was never marketed.
Mofegiline hydrochloride (CAS 120635-25-8) References
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Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Mofegiline hydrochloride, 250 mg | sc-269606 | 250 mg | $1300.00 | |||
Mofegiline hydrochloride, 1 g | sc-269606A | 1 g | $2889.00 |