Mofegiline hydrochloride CAS: 120635-25-8
MF: C11H13F2N•HCl
MW: 233.69
A selective, irreversible inhibitor of MAO-B and VAP-1.

Mofegiline hydrochloride (CAS 120635-25-8)

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Synonym: MDL-72,974
Application: A selective, irreversible inhibitor of MAO-B and VAP-1
CAS Number: 120635-25-8
Molecular Weight: 233.69
Molecular Formula: C11H13F2N•HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
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Mofegiline hydrochloride (MDL-72,974) is a selective, irreversible inhibitor of monoamine oxidase B (MAO-B) and amine oxidase, copper containing 3 (AOC3) or vascular adhesion protein 1 (VAP-1), also known as semicarbazide-sensitive amine oxidase (SSAO). Mofegiline was studied and extensively researched as a potential treatment of Parkinson′s disease and Alzheimer′s disease, but was never marketed.


References

1. Zreika, M., et al., 1989. MDL 72,974: a potent and selective enzyme-activated irreversible inhibitor of monoamine oxidase type B with potential for use in Parkinson′s disease. Journal of neural transmission. Parkinson′s disease and dementia section. 1(4): 243-54. PMID: 2597310
2. Palfreyman, M G., et al., 1988. Design and early clinical evaluation of selective inhibitors of monoamine oxidase. Progress in neuro-psychopharmacology & biological psychiatry. 12(6): 967-87. PMID: 3266532
3. Stoltz, M., et al., 1995. Pharmacokinetics and pharmacodynamics of the monoamine oxidase B inhibitor mofegiline assessed during a phase I dose tolerance trial. Clinical pharmacology and therapeutics. 58(3): 342-53. PMID: 7554709
4. Dow, J., et al., . Novel carbamate metabolites of mofegiline, a primary amine monoamine oxidase B inhibitor, in dogs and humans. Drug metabolism and disposition: the biological fate of chemicals. 22(5): 738-49. PMID: 7835226
5. Palfreyman, M G., et al., 1994. Haloallylamine inhibitors of MAO and SSAO and their therapeutic potential. Journal of neural transmission. Supplementum. 41(): 407-14. PMID: 7931257
6. Dulery, B D., et al., 1993. Pharmacokinetics of and monoamine oxidase B inhibition by (E)-4-fluoro-beta-fluoromethylene benzene butanamine in man. Arzneimittel-Forschung. 43(3): 297-302. PMID: 8489556
7. Thiffault, C., et al., 1998. Effect of the MAO-B inhibitor, MDL72974, on superoxide dismutase activity and lipid peroxidation levels in the mouse brain. Synapse (New York, N.Y.). 28(3): 208-11. PMID: 9488505

Physical State :
Solid
Storage :
Store at 4° C
Boiling Point :
322.7° C at 760 mmHg (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
6446650
MDL Number :
MFCD00890215
SMILES :
C1=CC(=CC=C1CC/C(=C\\F)/CN)F.Cl

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Certificate of Analysis

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What is the shipping temperature of this product?

Asked by: hawkeye11
This chemical, Mofegiline hydrochloride (CAS 120635-25-8), ships at ambient temperature.
Answered by: Chemical Support 1
Date published: 2017-03-15
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