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Moclobemide (CAS 71320-77-9)

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Application:
Moclobemide is a reversible monoamine oxidase inhibitor
CAS Number:
71320-77-9
Purity:
≥99%
Molecular Weight:
268.74
Molecular Formula:
C13H17ClN2O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Moclobemide is a reversible inhibitor of monoamine oxidase A (RIMA). It functions by binding to the enzyme and preventing the breakdown of monoamine neurotransmitters such as serotonin, norepinephrine, and dopamine. This inhibition leads to an increase in the levels of these neurotransmitters in the synaptic cleft, which can result in enhanced neurotransmission and modulation of mood, cognition, and behavior. Moclobemide′s mechanism of action involves specifically targeting and inhibiting the activity of monoamine oxidase A, which is responsible for the degradation of monoamine neurotransmitters. By doing so, it can modulate the levels of these neurotransmitters, potentially influencing various physiological and psychological processes.


Moclobemide (CAS 71320-77-9) References

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  2. Moclobemide: evolution, pharmacodynamic, and pharmacokinetic properties.  |  Bonnet, U. 2002. CNS Drug Rev. 8: 283-308. PMID: 12353059
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  4. RIMA: a safe concept in the treatment of depression with moclobemide.  |  Amrein, R., et al. 1992. Can J Psychiatry. 37 Suppl 1: 7-11. PMID: 1394030
  5. Biochemistry and pharmacology of moclobemide, a prototype RIMA.  |  Haefely, W., et al. 1992. Psychopharmacology (Berl). 106 Suppl: S6-14. PMID: 1546143
  6. From moclobemide to Ro 19-6327 and Ro 41-1049: the development of a new class of reversible, selective MAO-A and MAO-B inhibitors.  |  Da Prada, M., et al. 1990. J Neural Transm Suppl. 29: 279-92. PMID: 2193111
  7. Hypotensive action and weak potentiation of tyramine effect by moclobemide in rats.  |  Da Prada, M. and Burkard, WP. 1990. Acta Psychiatr Scand Suppl. 360: 106-7. PMID: 2248060
  8. The effects of moclobemide on cognition.  |  Wesnes, KA., et al. 1989. J Neural Transm Suppl. 28: 91-102. PMID: 2677245
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  10. RIMA--a new concept in the treatment of depression with moclobemide.  |  Amrein, R., et al. 1993. Int Clin Psychopharmacol. 7: 123-32. PMID: 8468432
  11. Moclobemide--placebo-controlled trials.  |  Silverstone, T. 1993. Int Clin Psychopharmacol. 7: 133-6. PMID: 8468433
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  14. Moclobemide in the treatment of social phobia.  |  Nutt, D. and Montgomery, SA. 1996. Int Clin Psychopharmacol. 11 Suppl 3: 77-82. PMID: 8923114

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Moclobemide, 10 mg

sc-207891
10 mg
$91.00