MO25 Antibody (919I2G): sc-517655

MO25 Antibody (919I2G) is a mouse monoclonal IgG1 kappa light chain antibody that detects MO25 protein of mouse, rat, and human origin by western blotting (WB). Anti-MO25 antibody (919I2G) is available as the non-conjugated format, providing researchers with a reliable tool for studying this important protein. MO25, also known as calcium binding protein 39, plays a crucial role in the regulation of the serine/threonine kinase LKB1, which is a key tumor suppressor involved in cellular energy homeostasis and metabolism. The interaction between MO25 and LKB1 is vital for proper localization and activation of LKB1, as MO25 facilitates LKB1 translocation from the nucleus to the cytoplasm, thereby enhancing tumor suppressor functions. Dysregulation of this complex can lead to impaired LKB1 activity, contributing to the development of Peutz-Jeghers Syndrome and increasing the risk of various cancers. MO25 (919I2G) antibody enables researchers to gain insights into the molecular mechanisms underlying LKB1 regulation and its implications in cancer biology.

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MO25 Antibody (919I2G) References:

1. LKB1 tumor suppressor protein: PARtaker in cell polarity.  |  Baas, AF., et al. 2004. Trends Cell Biol. 14: 312-9. PMID: 15183188
2. Endurance training increases LKB1 and MO25 protein but not AMP-activated protein kinase kinase activity in skeletal muscle.  |  Taylor, EB., et al. 2004. Am J Physiol Endocrinol Metab. 287: E1082-9. PMID: 15292028
3. Analysis of the LKB1-STRAD-MO25 complex.  |  Boudeau, J., et al. 2004. J Cell Sci. 117: 6365-75. PMID: 15561763
4. Long-chain acyl-CoA esters inhibit phosphorylation of AMP-activated protein kinase at threonine-172 by LKB1/STRAD/MO25.  |  Taylor, EB., et al. 2005. Am J Physiol Endocrinol Metab. 288: E1055-61. PMID: 15644453
5. Identification of the sucrose non-fermenting related kinase SNRK, as a novel LKB1 substrate.  |  Jaleel, M., et al. 2005. FEBS Lett. 579: 1417-23. PMID: 15733851
6. TOPORS, implicated in retinal degeneration, is a cilia-centrosomal protein.  |  Chakarova, CF., et al. 2011. Hum Mol Genet. 20: 975-87. PMID: 21159800
7. TOPORS modulates H2AX discriminating genotoxic stresses.  |  Seong, KM., et al. 2012. J Biochem Mol Toxicol. 26: 429-38. PMID: 22972498
8. TOPORS, a tumor suppressor protein, contributes to the maintenance of higher-order chromatin architecture.  |  Ji, L., et al. 2020. Biochim Biophys Acta Gene Regul Mech. 1863: 194518. PMID: 32113985
9. Mutations of TOPORS identified in families with retinitis pigmentosa.  |  He, K., et al. 2022. Ophthalmic Genet. 43: 371-377. PMID: 35254173
10. Concerted SUMO-targeted ubiquitin ligase activities of TOPORS and RNF4 are essential for stress management and cell proliferation.  |  Liu, JCY., et al. 2024. Nat Struct Mol Biol. 31: 1355-1367. PMID: 38649616
11. Inhibition of TOPORS ubiquitin ligase augments the efficacy of DNA hypomethylating agents through DNMT1 stabilization.  |  Kaito, S., et al. 2024. Nat Commun. 15: 7359. PMID: 39198387
12. Peutz-Jeghers syndrome is caused by mutations in a novel serine threonine kinase.  |  Jenne, DE., et al. 1998. Nat Genet. 18: 38-43. PMID: 9425897