Molecular structure of MnTBAP chloride, CAS Number: 55266-18-7
MnTBAP chloride (CAS 55266-18-7)
See product citations (39)
Alternate Names:
MnTBAP chloride is also known as Mn(III)TBAP (chloride).
Application:
MnTBAP chloride is a cell permeable superoxide dismutase mimetic and peroxynitrite reactive oxygen species (ROS) scavenger.
CAS Number:
55266-18-7
Purity:
≥97%
Molecular Weight:
879.15
Molecular Formula:
C48H28MnN4O8•Cl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
MnTBAP chloride is a cell permeable superoxide dismutase (SOD) mimetic and peroxynitrite scavenger. MnTBAP chloride is a potent inhibitor of peroxynitrite-induced oxidative reactions (peroxynitrite scavenger), but not a scavenger of nitric oxide (NO). In addition, MnTBAP chloride protects endothelial cells in a dose-dependent manner (EC50 ~40 µM) against paraquat (2 mM). MnTBAP chloride inhibits the oxidation of Dihydrorhodamine 123 by peroxynitrite. MnTBAP chloride inhibits neuronal apoptosis.
MnTBAP chloride (CAS 55266-18-7) References
- SOD mimetic improves the function, growth, and survival of small-size liver grafts after transplantation in rats. | Cui, YY., et al. 2012. Transplantation. 94: 687-94. PMID: 22955229
- Treatment with a SOD mimetic reduces visceral adiposity, adipocyte death, and adipose tissue inflammation in high fat-fed mice. | Pires, KM., et al. 2014. Obesity (Silver Spring). 22: 178-87. PMID: 23526686
- Angiotensin II activation of TRPC6 channels in rat podocytes requires generation of reactive oxygen species. | Anderson, M., et al. 2014. J Cell Physiol. 229: 434-42. PMID: 24037962
- The protective role of MnTBAP in oxidant-mediated injury and inflammation in a rat model of lung contusion. | Suresh, MV., et al. 2013. Surgery. 154: 980-90. PMID: 24139490
- MnTBAP Therapy Attenuates Renal Fibrosis in Mice with 5/6 Nephrectomy. | Yu, J., et al. 2016. Oxid Med Cell Longev. 2016: 7496930. PMID: 26989454
- MnTBAP Inhibits Bleomycin-Induced Pulmonary Fibrosis by Regulating VEGF and Wnt Signaling. | Venkatadri, R., et al. 2017. J Cell Physiol. 232: 506-516. PMID: 27649046
- The Magnaporthe oryzae nitrooxidative stress response suppresses rice innate immunity during blast disease. | Marroquin-Guzman, M., et al. 2017. Nat Microbiol. 2: 17054. PMID: 28418377
- Fluorescence quenching by metal centered porphyrins and poryphyrin enzymes. | Olson, KR., et al. 2017. Am J Physiol Regul Integr Comp Physiol. 313: R340-R346. PMID: 28835449
- iNOS- and NOX1-dependent ROS production maintains bacterial homeostasis in the ileum of mice. | Matziouridou, C., et al. 2018. Mucosal Immunol. 11: 774-784. PMID: 29210363
- Thioredoxin inhibitor PX-12 induces mitochondria-mediated apoptosis in acute lymphoblastic leukemia cells. | Ehrenfeld, V. and Fulda, S. 2020. Biol Chem. 401: 273-283. PMID: 31352431
- Ultrasensitive DNA electrochemical biosensor based on MnTBAP biomimetic catalyzed AGET ATRP signal amplification reaction. | Sun, H., et al. 2020. Chem Commun (Camb). 56: 6636-6639. PMID: 32406442
- Mitochondrial C3a Receptor Activation in Oxidatively Stressed Epithelial Cells Reduces Mitochondrial Respiration and Metabolism. | Ishii, M., et al. 2021. Front Immunol. 12: 628062. PMID: 33746964
- Paper-Based Multiplex Sensors for the Optical Detection of Plant Stress. | Zedler, M., et al. 2023. Micromachines (Basel). 14: PMID: 36838015
Inhibitor of:
Apoptosis.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MnTBAP chloride, 10 mg | sc-221954 | 10 mg | $44.00 | |||
MnTBAP chloride, 50 mg | sc-221954A | 50 mg | $102.00 |