Molecular structure of MNS, CAS Number: 1485-00-3
MNS (CAS 1485-00-3)
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Alternate Names:
Syk Inhibitor III
Application:
MNS is a selective inhibitor of Syk kinase activity
CAS Number:
1485-00-3
Purity:
≥99%
Molecular Weight:
193.16
Molecular Formula:
C9H7NO4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
MNS is a selective inhibitor of c-Src and Syk tyrosine kinases also known as 3,4-methylenedioxy-beta-nitrostyrene. MNS acts as a cell-permeable cytotoxic beta-nitrostyrene derivative which suppresses human platelet aggregation. In addition, platelets previously aggregated by ADP, U46619, arachidonic acid, collagen, thrombin, ionophore A23187, and PDBu can be disaggregated by MNS. Studies suggest the mechanism responsible for this inhibition is observed via prevention of glycoprotein IIb/IIIa activation.
MNS (CAS 1485-00-3) References
- Prevention of platelet glycoprotein IIb/IIIa activation by 3,4-methylenedioxy-beta-nitrostyrene, a novel tyrosine kinase inhibitor. | Wang, WY., et al. 2006. Mol Pharmacol. 70: 1380-9. PMID: 16837624
- The synthesis and biologic evaluation of anti-platelet and cytotoxic β-nitrostyrenes. | Hsieh, PW., et al. 2010. Bioorg Med Chem. 18: 7621-7. PMID: 20850977
- Osteosarcoma Phenotype Is Inhibited by 3,4-Methylenedioxy-β-nitrostyrene. | Messerschmitt, PJ., et al. 2012. Sarcoma. 2012: 479712. PMID: 22701331
- 3,4-methylenedioxy-β-nitrostyrene inhibits NLRP3 inflammasome activation by blocking assembly of the inflammasome. | He, Y., et al. 2014. J Biol Chem. 289: 1142-50. PMID: 24265316
- 3,4-Methylenedioxy-β-nitrostyrene inhibits adhesion and migration of human triple-negative breast cancer cells by suppressing β1 integrin function and surface protein disulfide isomerase. | Chen, IH., et al. 2015. Biochimie. 110: 81-92. PMID: 25593085
- Artemisinin protects mice against burn sepsis through inhibiting NLRP3 inflammasome activation. | Long, H., et al. 2016. Am J Emerg Med. 34: 772-7. PMID: 26830216
- 3,4-Methylenedioxy-β-Nitrostyrene Ameliorates Experimental Burn Wound Progression by Inhibiting the NLRP3 Inflammasome Activation. | Xiao, M., et al. 2016. Plast Reconstr Surg. 137: 566e-575e. PMID: 26910701
- Challenges in the evaluation of thiol-reactive inhibitors of human protein disulfide Isomerase. | Foster, CK. and Thorpe, C. 2017. Free Radic Biol Med. 108: 741-749. PMID: 28465261
- Visualization and quantification of dynamic STAT3 homodimerization in living cells using homoFluoppi. | Okada, Y., et al. 2018. Sci Rep. 8: 2385. PMID: 29402895
- Biomolecular interaction of a platelet aggregation inhibitor, 3,4-methylenedioxy-β-nitrostyrene with human serum albumin: multi-spectral and computational characterization. | Kabir, MZ., et al. 2020. J Biomol Struct Dyn. 38: 2693-2703. PMID: 31271347
- Immune Cells Combined With NLRP3 Inflammasome Inhibitor Exert Better Antitumor Effect on Pancreatic Ductal Adenocarcinoma. | Liu, H., et al. 2020. Front Oncol. 10: 1378. PMID: 32974137
- 3,4-Methylenedioxy-β-Nitrostyrene Alleviates Dextran Sulfate Sodium-Induced Mouse Colitis by Inhibiting the NLRP3 Inflammasome. | Zheng, J., et al. 2022. Front Pharmacol. 13: 866228. PMID: 35784693
- Targeting the PANoptosome with 3,4-Methylenedioxy-β-Nitrostyrene, Reduces PANoptosis and Protects the Kidney against Renal İschemia-Reperfusion Injury. | Uysal, E., et al. 2022. J Invest Surg. 35: 1824-1835. PMID: 36170987
Inhibitor of:
c-Src, Syk, and USP5.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MNS, 50 mg | sc-202229 | 50 mg | $87.00 |