Molecular structure of Mn-cpx 3
Mn-cpx 3
See product citations (1)
Application:
Mn-cpx 3 is a cell-permeable SOD mimetic
Molecular Weight:
602.3
Molecular Formula:
C30H20Cl2MnO6
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Mn-cpx 3 is a cell-permeable manganese complex of 7-hydroxyflavone that acts as a superoxide dismustase (SOD) mimetic and a neuroprotective agent against radical-induced damages. Shown to prevent the reduction of NBT by O2– • (IC50 = 1.18 μM) and exhibit ~10 times higher potency than Trolox in inhibiting lipid peroxidation (IC50 = 6.15 μM) in vitro.
Mn-cpx 3 References
- Manganese-based complexes of radical scavengers as neuroprotective agents. | Vajragupta, O., et al. 2003. Bioorg Med Chem. 11: 2329-37. PMID: 12713845
- Reactive oxygen species contribute to Ca2+ signals produced by osmotic stress in mouse skeletal muscle fibres. | Martins, AS., et al. 2008. J Physiol. 586: 197-210. PMID: 17974587
- Dystrophic cardiomyopathy: amplification of cellular damage by Ca2+ signalling and reactive oxygen species-generating pathways. | Jung, C., et al. 2008. Cardiovasc Res. 77: 766-73. PMID: 18056762
- alpha-melanocyte-stimulating hormone suppresses bleomycin-induced collagen synthesis and reduces tissue fibrosis in a mouse model of scleroderma: melanocortin peptides as a novel treatment strategy for scleroderma? | Kokot, A., et al. 2009. Arthritis Rheum. 60: 592-603. PMID: 19180474
- Reciprocal amplification of ROS and Ca(2+) signals in stressed mdx dystrophic skeletal muscle fibers. | Shkryl, VM., et al. 2009. Pflugers Arch. 458: 915-28. PMID: 19387681
- NADPH oxidase NOX2 mediates rapid cellular oxidation following ATP stimulation of endotoxin-primed macrophages. | Moore, SF. and MacKenzie, AB. 2009. J Immunol. 183: 3302-8. PMID: 19696433
- A nonapoptotic role for CASP2/caspase 2: modulation of autophagy. | Tiwari, M., et al. 2014. Autophagy. 10: 1054-70. PMID: 24879153
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Mn-cpx 3, 25 mg | sc-221951 | 25 mg | $399.00 |