MMS19 Antibody (G-12): sc-390028
- MMS19 Antibody (G-12) is a mouse monoclonal IgG2a κ provided at 200 µg/ml
- raised against amino acids 366-665 mapping within an internal region of MMS19 of human origin
- MMS19 Antibody (G-12) is recommended for detection of MMS19 of human origin by WB, IP, IF and ELISA
- Anti-MMS19 Antibody (G-12) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- TransCruz reagent for ChIP application (sc-390028 X, 200 µg/0.1 ml)
- m-IgGκ BP-HRP is the preferred secondary detection reagent for MMS19 Antibody (G-12) for WB applications. This reagent is now offered in a bundle with MMS19 Antibody (G-12) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
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MMS19 Antibody (G-12) is a mouse monoclonal IgG2a kappa light chain antibody that detects MMS19 of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). MMS19 (G-12) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. MMS19, also known as MMS19 nucleotide excision repair homolog or MET18, is a crucial 1,030 amino acid nuclear protein characterized by seven HEAT repeats and belonging to the MET18/MMS19 family. MMS19 plays a vital role in nucleotide excision repair (NER) and RNA polymerase II transcription through interactions with TFIIH p80 and TFIIH p89 helicases, which are essential for maintaining genomic stability and proper gene expression. Additionally, MMS19 may act as a transcriptional coactivator of the estrogen receptor, highlighting its importance in cellular signaling pathways. While MMS19 is ubiquitously expressed, MMS19 is found at the highest levels in the testis, indicating a potential role in reproductive biology. The gene encoding MMS19 is located on human chromosome 10q24.1 and has been associated with an increased risk of pancreatic cancer, underscoring its significance in cancer research. Notably, at least five distinct isoforms of MMS19 exist due to alternative splicing, which may contribute to its diverse functional roles in cellular processes.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
MMS19 Antibody (G-12) References:
- Cloning of a human homolog of the yeast nucleotide excision repair gene MMS19 and interaction with transcription repair factor TFIIH via the XPB and XPD helicases. | Seroz, T., et al. 2000. Nucleic Acids Res. 28: 4506-13. PMID: 11071939
- The human homologue of the yeast DNA repair and TFIIH regulator MMS19 is an AF-1-specific coactivator of estrogen receptor. | Wu, X., et al. 2001. J Biol Chem. 276: 23962-8. PMID: 11279242
- Cloning the human and mouse MMS19 genes and functional complementation of a yeast mms19 deletion mutant. | Queimado, L., et al. 2001. Nucleic Acids Res. 29: 1884-91. PMID: 11328871
- Identification of MMS19 domains with distinct functions in NER and transcription. | Hatfield, MD., et al. 2006. DNA Repair (Amst). 5: 914-24. PMID: 16797255
- Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. | Daub, H., et al. 2008. Mol Cell. 31: 438-48. PMID: 18691976
- Nucleotide excision repair pathway polymorphisms and pancreatic cancer risk: evidence for role of MMS19L. | McWilliams, RR., et al. 2009. Cancer Epidemiol Biomarkers Prev. 18: 1295-302. PMID: 19318433
- Lysine acetylation targets protein complexes and co-regulates major cellular functions. | Choudhary, C., et al. 2009. Science. 325: 834-40. PMID: 19608861
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MMS19 Antibody (G-12) | sc-390028 | 200 µg/ml | $322.00 | |||
MMS19 Antibody (G-12): m-IgGκ BP-HRP Bundle | sc-523374 | 200 µg Ab, 40 µg BP | $361.00 | |||
MMS19 Antibody (G-12) X | sc-390028 X | 200 µg/0.1 ml | $322.00 | |||
MMS19 Antibody (G-12) AC | sc-390028 AC | 500 µg/ml, 25% agarose | $424.00 | |||
MMS19 Antibody (G-12) HRP | sc-390028 HRP | 200 µg/ml | $322.00 | |||
MMS19 Antibody (G-12) FITC | sc-390028 FITC | 200 µg/ml | $336.00 | |||
MMS19 Antibody (G-12) PE | sc-390028 PE | 200 µg/ml | $349.00 | |||
MMS19 Antibody (G-12) Alexa Fluor® 488 | sc-390028 AF488 | 200 µg/ml | $364.00 | |||
MMS19 Antibody (G-12) Alexa Fluor® 546 | sc-390028 AF546 | 200 µg/ml | $364.00 | |||
MMS19 Antibody (G-12) Alexa Fluor® 594 | sc-390028 AF594 | 200 µg/ml | $364.00 | |||
MMS19 Antibody (G-12) Alexa Fluor® 647 | sc-390028 AF647 | 200 µg/ml | $364.00 | |||
MMS19 Antibody (G-12) Alexa Fluor® 680 | sc-390028 AF680 | 200 µg/ml | $364.00 | |||
MMS19 Antibody (G-12) Alexa Fluor® 790 | sc-390028 AF790 | 200 µg/ml | $364.00 |