Molecular structure of MMPIP hydrochloride, CAS Number: 479077-02-6
MMPIP hydrochloride (CAS 479077-02-6)
Alternate Names:
6-(4-Methoxyphenyl)-5-methyl-3-(4-pyridinyl)-isoxazolo[4,5-c]pyridin-4(5H)-one hydrochloride
Application:
MMPIP hydrochloride is a potent allosteric mGlu7-selective receptor antagonist
CAS Number:
479077-02-6
Molecular Weight:
369.8
Molecular Formula:
C19H15N3O3•HCl
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Available in US only.
Available in US only.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
MMPIP hydrochloride is a potent allosteric mGluR-7-selective receptor antagonist. MMPIP hydrochloride inhibits agonist-induced intracellular calcium mobilization and cAMP accumulation (IC50 values are 26 and 610 nM). Displays intrinsic activity increases forskolin-induced cAMP accumulation in the absence of an agonist (IC50 = 15 nM), indicating inverse agonist activity.
MMPIP hydrochloride (CAS 479077-02-6) References
- In silico molecular comparisons of C. elegans and mammalian pharmacology identify distinct targets that regulate feeding. | Lemieux, GA., et al. 2013. PLoS Biol. 11: e1001712. PMID: 24260022
- Investigating glutamatergic mechanism in attention and impulse control using rats in a modified 5-choice serial reaction time task. | Benn, A. and Robinson, ES. 2014. PLoS One. 9: e115374. PMID: 25526617
- Optogenetic Stimulation of Prefrontal Glutamatergic Neurons Enhances Recognition Memory. | Benn, A., et al. 2016. J Neurosci. 36: 4930-9. PMID: 27147648
Inhibitor of:
mGluR-7.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MMPIP hydrochloride, 1 mg | sc-204093 | 1 mg | $85.00 | |||
| US: Only available in the US | ||||||
MMPIP hydrochloride, 10 mg | sc-204093A | 10 mg | $180.00 | |||
| US: Only available in the US | ||||||