Molecular structure of MMP-9/MMP-13 Inhibitor II
MMP-9/MMP-13 Inhibitor II
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Application:
MMP-9/MMP-13 Inhibitor II is a potent inhibitor of MMP-9 and MMP-13
Molecular Weight:
449.5
Molecular Formula:
C20H23N3O7S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
MMP-9/MMP-13 Inhibitor II is a piperazine-based, cell-permeable, and highly potent inhibitor of MMP-9 (IC50 = 900 pM) and MMP-13 (IC50 = 900 pM). MMP-9/MMP-13 Inhibitor II has been reported to inhibit MMP-1 and MMP-3 at much higher concentrations (IC50 = 43 nM and 23 nM, respectively). Also acts as an inhibitor of MMP-7 (IC50 = 930 nM).
MMP-9/MMP-13 Inhibitor II References
- Design and synthesis of piperazine-based matrix metalloproteinase inhibitors. | Cheng, M., et al. 2000. J Med Chem. 43: 369-80. PMID: 10669564
- Protease inhibitor treatments reveal specific involvement of matrix metalloproteinase-9 in human adipocyte differentiation. | Bourlier, V., et al. 2005. J Pharmacol Exp Ther. 312: 1272-9. PMID: 15537822
- Methyl mercury suppresses the formation of the tail primordium in developing zebrafish embryos. | Yang, L., et al. 2010. Toxicol Sci. 115: 379-90. PMID: 20181659
- Matrix metalloproteinase-19 inhibits growth of endothelial cells by generating angiostatin-like fragments from plasminogen. | Brauer, R., et al. 2011. BMC Biochem. 12: 38. PMID: 21787393
- β1-adrenergic receptor N-terminal cleavage by ADAM17; the mechanism for redox-dependent downregulation of cardiomyocyte β1-adrenergic receptors. | Zhu, J. and Steinberg, SF. 2021. J Mol Cell Cardiol. 154: 70-79. PMID: 33556394
Inhibitor of:
MMP-13, and MMP-9.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MMP-9/MMP-13 Inhibitor II, 1 mg | sc-311439 | 1 mg | $218.00 |