MMP-9/MMP-13 inhibitor I (CAS 204140-01-2)
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MMP-9/MMP-13 Inhibitor I is a piperazine-based, cell-permeable, and highly potent inhibitor of MMP-9 (IC50 = 900 pM) and MMP-13 (IC50 = 900 pM). Reported to inhibit MMP-1 and MMP-3 at much higher concentrations (IC50 = 43 nM and 23 nM, respectively). Also acts as an inhibitor of MMP-7 (IC50 = 930 nM)(MMPs) are a group of zinc-dependent endopeptidases that play a vital role in processes like tissue remodeling and inflammation. Among these, MMP-9 and MMP-13 are prominent members responsible for breaking down extracellular matrix proteins. One such promising inhibitor, known as MMP-9/MMP-13 inhibitor I, has undergone extensive research. Moreover, scientists have explored MMP-9/MMP-13 inhibitor I′s ability to modulate the inflammatory response.
MMP-9/MMP-13 inhibitor I (CAS 204140-01-2) References
- Design and synthesis of piperazine-based matrix metalloproteinase inhibitors. | Cheng, M., et al. 2000. J Med Chem. 43: 369-80. PMID: 10669564
- Phagocytosis of hemozoin enhances matrix metalloproteinase-9 activity and TNF-alpha production in human monocytes: role of matrix metalloproteinases in the pathogenesis of falciparum malaria. | Prato, M., et al. 2005. J Immunol. 175: 6436-42. PMID: 16272296
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MMP-9/MMP-13 inhibitor I, 1 mg | sc-311438 | 1 mg | $173.00 | |||
MMP-9/MMP-13 inhibitor I, 5 mg | sc-311438A | 5 mg | $536.00 |