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MMP-9 Inhibitor I (CAS 1177749-58-4) - chemical structure image
Molecular structure of MMP-9 Inhibitor I, CAS Number: 1177749-58-4
MMP-9 Inhibitor I (CAS 1177749-58-4) - chemical structure image
Molecular structure of MMP-9 Inhibitor I, CAS Number: 1177749-58-4
Molecular structure of MMP-9 Inhibitor I, CAS Number: 1177749-58-4

MMP-9 Inhibitor I (CAS 1177749-58-4)

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Alternate Names:
CTK8G1150; AG-L-66085
Application:
MMP-9 Inhibitor I is a cell-permeable and reversible MMP-9 inhibitor
CAS Number:
1177749-58-4
Purity:
≥93%
Molecular Weight:
511.6
Molecular Formula:
C27H33N3O5S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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SDS & Certificate of Analysis

MMP-9 Inhibitor I is a cell permeable reversible inhibitor of MMP-9. At high concentrations, this inhibitor suppresses MMP-1 and MMP-13. MMPs are essential in the breakdown of the extracellular matrix. In addition, MMP-9 has an important role in tumor cell migration, tumor cell invasion, and angiogenesis. This suggests that MMP-9 Inhibitor I can possibly be used to inhibit these cell processes.


MMP-9 Inhibitor I (CAS 1177749-58-4) References

  1. Biochemistry and molecular biology of gelatinase B or matrix metalloproteinase-9 (MMP-9).  |  Van den Steen, PE., et al. 2002. Crit Rev Biochem Mol Biol. 37: 375-536. PMID: 12540195
  2. MMP-9 overexpression improves myogenic cell migration and engraftment.  |  Morgan, J., et al. 2010. Muscle Nerve. 42: 584-95. PMID: 20734311
  3. Localization of uPAR and MMP-9 in lipid rafts is critical for migration, invasion and angiogenesis in human breast cancer cells.  |  Raghu, H., et al. 2010. BMC Cancer. 10: 647. PMID: 21106094
  4. The role of matrix metalloproteinases (MMPs) and their inhibitors (TIMPs) in the development of esophageal cancer.  |  Groblewska, M., et al. 2012. Folia Histochem Cytobiol. 50: 12-9. PMID: 22532131
  5. Role of MMP-9 in the breakdown of barrier integrity of the corneal endothelium in response to TNF-α.  |  Rajashekhar, G., et al. 2014. Exp Eye Res. 122: 77-85. PMID: 24667088
  6. Promotion of lung tumor growth by interleukin-17.  |  Xu, B., et al. 2014. Am J Physiol Lung Cell Mol Physiol. 307: L497-508. PMID: 25038189
  7. Morphine alters the circulating proteolytic profile in mice: functional consequences on cellular migration and invasion.  |  Xie, N., et al. 2017. FASEB J. 31: 5208-5216. PMID: 28784632
  8. Matrix Metalloproteinase 9 Displays a Particular Time Response to Acute Stress: Variation in Its Levels and Activity Distribution in Rat Hippocampus.  |  Aguayo, FI., et al. 2018. ACS Chem Neurosci. 9: 945-956. PMID: 29361213
  9. Yokukansan Alleviates Cancer Pain by Suppressing Matrix Metalloproteinase-9 in a Mouse Bone Metastasis Model.  |  Nakao, K., et al. 2019. Evid Based Complement Alternat Med. 2019: 2956920. PMID: 31239855
  10. Acetylcholine Receptor Activation as a Modulator of Glioblastoma Invasion.  |  Thompson, EG. and Sontheimer, H. 2019. Cells. 8: PMID: 31590360
  11. Homocysteine Disrupts Balance between MMP-9 and Its Tissue Inhibitor in Diabetic Retinopathy: The Role of DNA Methylation.  |  Mohammad, G. and Kowluru, RA. 2020. Int J Mol Sci. 21: PMID: 32150828
  12. MMP9 inhibition increases autophagic flux in chronic heart failure.  |  Nandi, SS., et al. 2020. Am J Physiol Heart Circ Physiol. 319: H1414-H1437. PMID: 33064567
  13. MMP-9 mediated Syndecan-4 shedding correlates with osteoarthritis severity.  |  Bollmann, M., et al. 2021. Osteoarthritis Cartilage. 29: 280-289. PMID: 33246160
  14. The SWI/SNF-Related, Matrix Associated, Actin-Dependent Regulator of Chromatin A4 Core Complex Represses Respiratory Syncytial Virus-Induced Syncytia Formation and Subepithelial Myofibroblast Transition.  |  Xu, X., et al. 2021. Front Immunol. 12: 633654. PMID: 33732255
  15. CD99 antibody disrupts T-cell acute lymphoblastic leukemia adhesion to meningeal cells and attenuates chemoresistance.  |  Ebadi, M., et al. 2021. Sci Rep. 11: 24374. PMID: 34934147
  16. Caspase-9 inhibition decreases expression of Mmp9 during chondrogenesis.  |  Ramesova, A., et al. 2022. Histochem Cell Biol. 157: 403-413. PMID: 34999953

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

MMP-9 Inhibitor I, 500 µg

sc-311437
500 µg
$250.00

Can you please describe how this inhibitor inhibits MMP9?

Asked by: entropy
Thank you for contacting Santa Cruz Biotechnology. Inhibitor of MMP-9 (IC50 = 5 nM). Also inhibits MMP-1 (IC50 = 1.05 µM) and MMP-13 IC50 = 113 nM) at higher concentrations. Here is some literature that might be helpful on binding: Tandon A, Sinha S. Structural insights into the binding of MMP9 inhibitors. Bioinformation. 2011 Jan 22;5(8):310-4. doi: 10.6026/97320630005310. PMID: 21383916
Answered by: BlakeJ
Date published: 2024-06-26

Have you measured its ability to inhibit MMP-9? How can I check the its ability?

Asked by: office
Thank you for your question. We have not measured inhibition ability, but here is some literature that may be helpful: Van den Steen, P.E. et al. 2002. Crit. Rev. Biochem. Mol. Biol. 37(6): 375-536. PMID: 12540195 Groblewska, M. et al. 2012. Folia Histochem. Cytobiol. 50(1): 12-19. PMID: 22532131
Answered by: Technical Support
Date published: 2024-03-28

which forms of MMP 9 (pro,active) are inhibited by this inhibitor?

Asked by: seethal
Thank you for your question. We do not have this information available. Please refer to the references on our website for additional information.
Answered by: Technical Support
Date published: 2024-03-28
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Rated 5 out of 5 by from Various publications cite MMPVarious publications cite MMP-9 Inhibitor I as a cell permeable reversible inhibitor of MMP-9. At high concentrations this inhibitor suppresses MMP-1 and MMP-13. -SCBT Publication Review
Date published: 2015-04-02
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MMP-9 Inhibitor I is rated 5.0 out of 5 by 1.
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