Molecular structure of MMP-8 Inhibitor I, CAS Number: 236403-25-1
MMP-8 Inhibitor I (CAS 236403-25-1)
See product citations (6)
Alternate Names:
(3R)-N-hydroxy-2-(4-methoxyphenyl)sulfonyl-3,4-dihydro-1H-isoquinoline-3-carboxamide
Application:
MMP-8 Inhibitor I is a potent, cell-permeable MMP-8 inhibitor
CAS Number:
236403-25-1
Purity:
≥95%
Molecular Weight:
362.40
Molecular Formula:
C17H18N2O5S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
MMP-8 Inhibitor I is utilized in research focused on matrix metalloproteinases, specifically matrix metalloproteinase-8 (MMP-8), which is known to degrade collagen and other components of the extracellular matrix. By inhibiting MMP-8, this compound allows for the study of the enzyme′s role in tissue remodeling, wound healing, and various pathological conditions such as fibrosis and cancer metastasis. Research with MMP-8 Inhibitor I helps to elucidate the balance between matrix synthesis and degradation, providing insights into the regulation of extracellular matrix integrity. It is also used to explore the potential of modulating MMP activity in conditions where excessive or insufficient extracellular matrix degradation is implicated.
MMP-8 Inhibitor I (CAS 236403-25-1) References
- Quantitative structure-activity relationship of human neutrophil collagenase (MMP-8) inhibitors using comparative molecular field analysis and X-ray structure analysis. | Matter, H., et al. 1999. J Med Chem. 42: 1908-20. PMID: 10354399
- An MMP-2/MMP-9 inhibitor, 5a, enhances apoptosis induced by ligands of the TNF receptor superfamily in cancer cells. | Nyormoi, O., et al. 2003. Cell Death Differ. 10: 558-69. PMID: 12728254
- Vascular endothelial growth factor (VEGF) induces rapid prourokinase (pro-uPA) activation on the surface of endothelial cells. | Prager, GW., et al. 2004. Blood. 103: 955-62. PMID: 14525763
- Ectodomain shedding of the glycoprotein GP of Ebola virus. | Dolnik, O., et al. 2004. EMBO J. 23: 2175-84. PMID: 15103332
- Insulin-like growth factor binding protein-5 is a target of matrix metalloproteinase-7: implications for epithelial-mesenchymal signaling. | Hemers, E., et al. 2005. Cancer Res. 65: 7363-9. PMID: 16103088
- Metalloproteinase 9 is the outer executioner of desmoglein 3 in apoptotic keratinocytes. | Cirillo, N., et al. 2007. Oral Dis. 13: 341-5. PMID: 17448220
- Defining the role of matrix compliance and proteolysis in three-dimensional cell spreading and remodeling. | Dikovsky, D., et al. 2008. Biophys J. 94: 2914-25. PMID: 18178662
- Inhibition of matrix metalloproteinases enhances in vitro repair of the meniscus. | McNulty, AL., et al. 2009. Clin Orthop Relat Res. 467: 1557-67. PMID: 18975039
- Neisseria meningitidis induces brain microvascular endothelial cell detachment from the matrix and cleavage of occludin: a role for MMP-8. | Schubert-Unkmeir, A., et al. 2010. PLoS Pathog. 6: e1000874. PMID: 20442866
- The role of matrix metalloproteinases in regulating neuronal and nonneuronal cell invasion into PEGylated fibrinogen hydrogels. | Sarig-Nadir, O. and Seliktar, D. 2010. Biomaterials. 31: 6411-6. PMID: 20537384
- Matrix metalloproteinase-8 mediates the unfavorable systemic impact of local irradiation on pharmacokinetics of anti-cancer drug 5-Fluorouracil. | Hsieh, CH., et al. 2011. PLoS One. 6: e21000. PMID: 21695264
- Matrix metalloproteinase-8 is involved in dermal nerve growth: implications for possible application to pruritus from in vitro models. | Tominaga, M., et al. 2011. J Invest Dermatol. 131: 2105-12. PMID: 21697883
- Hox10-regulated endodermal cell migration is essential for development of the ascidian intestine. | Kawai, N., et al. 2015. Dev Biol. 403: 43-56. PMID: 25888074
- Role of Matrix Metalloproteinases-1 and -2 in Interleukin-13-Suppressed Elastin in Airway Fibroblasts in Asthma. | Ingram, JL., et al. 2016. Am J Respir Cell Mol Biol. 54: 41-50. PMID: 26074138
- Effect of matrix metalloproteinase 8 inhibitor on resin-dentin bonds. | Ou, Q., et al. 2018. Dent Mater. 34: 756-763. PMID: 29449021
- Effect of matrix metalloproteinase 8 inhibitor and chlorhexidine on the cytotoxicity, oxidative stress and cytokine level of MDPC-23. | Ou, Q., et al. 2018. Dent Mater. 34: e301-e308. PMID: 30236973
Inhibitor of:
MMP-8, and Protease.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MMP-8 Inhibitor I, 1 mg | sc-311436 | 1 mg | $194.00 | |||
MMP-8 Inhibitor I, 10 mg | sc-311436A | 10 mg | $1693.00 | |||
MMP-8 Inhibitor I, 100 mg | sc-311436B | 100 mg | $14045.00 |