MMP-3 Inhibitor VIII (CAS 208663-26-7)
Application:
MMP-3 Inhibitor VIII is a potent human MMP-3 and MME/MMP-12 inhibitor
CAS Number:
208663-26-7
Purity:
≥98%
Molecular Weight:
406.5
Molecular Formula:
C20H26N2O5S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
MMP-3 Inhibitor VIII is a cell permeable p-methoxysulfonamido D-leucine-containing hydroxamate compound. This compound functions as a potent inhibitor of human MMP-3 and murine macrophage metalloelastase MME/MMP-12. Studies indicate that MMP-3 Inhibitor VIII binds to the active site of MMP-3. MMP-3 is a protein which is involved in the breakdown of the extracellular matrix. These proteins are secreted as proproteins, which are activated via cleavage by proteinases.
MMP-3 Inhibitor VIII (CAS 208663-26-7) References
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- A substrate-optimized electrophoretic mobility shift assay for ADAM12. | Kotzsch, A., et al. 2014. Anal Biochem. 452: 34-42. PMID: 24534253
- Pharmacological Inhibition of MMP3 as a Potential Therapeutic Option for COVID-19 Associated Acute Respiratory Distress Syndrome. | Kadry, R., et al. 2021. Infect Disord Drug Targets. 21: e170721187996. PMID: 33200717
- Gene expression profiles in COVID-19-associated tracheal stenosis indicate persistent anti-viral response and dysregulated retinol metabolism. | Martins, RS., et al. 2024. BMC Res Notes. 17: 140. PMID: 38755665
- Discovery of CGS 27023A, a non-peptidic, potent, and orally active stromelysin inhibitor that blocks cartilage degradation in rabbits. | MacPherson, LJ., et al. 1997. J Med Chem. 40: 2525-32. PMID: 9258358
- Sulfonamide-based hydroxamic acids as potent inhibitors of mouse macrophage metalloelastase. | Jeng, AY., et al. 1998. Bioorg Med Chem Lett. 8: 897-902. PMID: 9871508
Inhibitor of:
Enzyme, MMP-12, and MMP-3.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MMP-3 Inhibitor VIII, 5 mg | sc-311435 | 5 mg | $400.00 |