Molecular structure of MMP-3 Inhibitor V, CAS Number: 185672-77-9
MMP-3 Inhibitor V (CAS 185672-77-9)
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Alternate Names:
4-Dibenzofuran-2′-yl-4-hydroximino-butyric Acid
Application:
MMP-3 Inhibitor V is a competitive and potent inhibitor of MMP-3 catalytic domains
CAS Number:
185672-77-9
Molecular Weight:
283.28
Molecular Formula:
C16H13NO4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
MMP-3 Inhibitor V is a potent and competitive inhibitor of both human and rabbit MMP-3 catalytic domains (wild type and mutants) with Ki values in the low μM range. It is shown that the functional groups, namely the oxime and the carboxyl, interact with the active site zinc.
MMP-3 Inhibitor V (CAS 185672-77-9) References
- Effect of species differences on stromelysin-1 (MMP-3) inhibitor potency. An explanation of inhibitor selectivity using homology modeling and chimeric proteins. | Johnson, LL., et al. 1999. J Biol Chem. 274: 24881-7. PMID: 10455161
- Combination of ciclopirox olamine and sphingosine-1-phosphate as granulation enhancer in diabetic wounds. | Lim, NS., et al. 2016. Wound Repair Regen. 24: 795-809. PMID: 27402256
- Pharmacological Inhibition of MMP3 as a Potential Therapeutic Option for COVID-19 Associated Acute Respiratory Distress Syndrome. | Kadry, R., et al. 2021. Infect Disord Drug Targets. 21: e170721187996. PMID: 33200717
- Gene expression profiles in COVID-19-associated tracheal stenosis indicate persistent anti-viral response and dysregulated retinol metabolism. | Martins, RS., et al. 2024. BMC Res Notes. 17: 140. PMID: 38755665
Inhibitor of:
MMP-3.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MMP-3 Inhibitor V, 5 mg | sc-311434 | 5 mg | $172.00 |