MMP-2/MMP-9 Inhibitor II (CAS 193807-60-2)
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Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases involved in various physiological and pathological processes, including tissue remodeling, wound healing, and cancer progression. Among these enzymes, MMP-2 and MMP-9 have garnered significant attention due to their implication in diseases like cancer, arthritis, and cardiovascular disorders. MMP-2/MMP-9 inhibitor II (MMP-2/MMP-9iII) is a small molecule that effectively inhibits both MMP-2 and MMP-9, and extensive research has examined its potential applications. MMP-2/MMP-9 inhibitor II has been the subject of comprehensive studies, offering a wide range of possibilities for scientific research. In vitro investigations have utilized MMP-2/MMP-9 inhibitor II to explore the roles of MMP-2 and MMP-9 in cancer progression, tissue remodeling, and wound healing. Moreover, this inhibitor has been evaluated in animal models of arthritis, cardiovascular diseases, and other conditions. Researchers have also explored the synergistic effects of MMP-2/MMP-9 inhibitor II when combined with other agents. Functioning as a small molecule inhibitor, MMP-2/MMP-9 inhibitor II acts by binding to the active sites of MMP-2 and MMP-9, effectively impeding their enzymatic activity. MMP-2/MMP-9 Inhibitor II may act to induce and rapidly activate HIF. Also reported to inhibit Lewis lung carcinoma-induced lung colonization in a murine model. This inhibition has demonstrated promising outcomes in reducing the progression of cancer, arthritis, and various diseases in animal models.
MMP-2/MMP-9 Inhibitor II (CAS 193807-60-2) References
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- An MMP-2/MMP-9 inhibitor, 5a, enhances apoptosis induced by ligands of the TNF receptor superfamily in cancer cells. | Nyormoi, O., et al. 2003. Cell Death Differ. 10: 558-69. PMID: 12728254
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- Salvianolic acid B attenuates MMP-2 and MMP-9 expression in vivo in apolipoprotein-E-deficient mouse aorta and in vitro in LPS-treated human aortic smooth muscle cells. | Lin, SJ., et al. 2007. J Cell Biochem. 100: 372-84. PMID: 16924668
- Claudin-1 overexpression in melanoma is regulated by PKC and contributes to melanoma cell motility. | Leotlela, PD., et al. 2007. Oncogene. 26: 3846-56. PMID: 17160014
- Activation of NMDA receptors promotes dendritic spine development through MMP-mediated ICAM-5 cleavage. | Tian, L., et al. 2007. J Cell Biol. 178: 687-700. PMID: 17682049
- Glucocorticoids alter craniofacial development and increase expression and activity of matrix metalloproteinases in developing zebrafish (Danio rerio). | Hillegass, JM., et al. 2008. Toxicol Sci. 102: 413-24. PMID: 18281261
- A disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS-4) cleaves Reelin in an isoform-dependent manner. | Hisanaga, A., et al. 2012. FEBS Lett. 586: 3349-53. PMID: 22819337
- Role of G protein-coupled estrogen receptor-1, matrix metalloproteinases 2 and 9, and heparin binding epidermal growth factor-like growth factor in estradiol-17β-stimulated bovine satellite cell proliferation. | Kamanga-Sollo, E., et al. 2014. Domest Anim Endocrinol. 49: 20-6. PMID: 25010024
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Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MMP-2/MMP-9 Inhibitor II, 1 mg | sc-311430 | 1 mg | $305.00 |