MMP-2/MMP-9 Inhibitor II CAS: 193807-60-2
MF: C21H20N2O4S
MW: 396.46
A potent inhibitor of MMP-2 and MMP-9.

MMP-2/MMP-9 Inhibitor II (CAS 193807-60-2)

MMP-2/MMP-9 Inhibitor II | CAS 193807-60-2 is rated 5.0 out of 5 by 1.
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Alternate Names: (2R)-N-hydroxy-3-phenyl-2-[(4-phenylphenyl)sulfonylamino]propanamide
Application: MMP-2/MMP-9 Inhibitor II is a potent inhibitor of MMP-2 and MMP-9
CAS Number: 193807-60-2
Purity: ≥95%
Molecular Weight: 396.46
Molecular Formula: C21H20N2O4S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

MMP-2/MMP-9 Inhibitor II is a potent inhibitor of MMP-2 (IC50 = 17 nM) and MMP-9 (IC50 = 30 nM). MMP-2/MMP-9 Inhibitor II has been shown to induce and rapidly activate HIF. Also reported to inhibit Lewis lung carcinoma-induced lung colonization in a murine model.


References

1. Mifune, M., et al. 2005. J. Biol. Chem. 280: 26592-26599. PMID: 15905175
2. Zhang, H., et al. 2004. Circ. Res. 95: 989-997. PMID: 15486316
3. Tamura, Y., et al. 1998. J. Med. Chem. 41: 640-649. PMID: 9484512
.

Physical State :
Solid
Solubility :
Soluble in DMSO (100 mg/ml), and methanol (25 mg/ml).
Storage :
Store at -20° C
Melting Point :
282.12° C (Predicted)
Boiling Point :
648.82° C (Predicted)
Density :
1.31 g/cm3 (Predicted)
Refractive Index :
n20D 1.63 (Predicted)
IC50 :
MMP-2: IC50 = 17 nM; MMP-9: IC50 = 30 nM
pK Values :
pKa: 9.03 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
9822095
MDL Number :
MFCD02683958
SMILES :
C1=CC=C(C=C1)C[[email protected]](C(=O)NO)NS(=O)(=O)C2=CC=C(C=C2)C3=CC=CC=C3

Download SDS (MSDS)

Certificate of Analysis

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MMP-2/MMP-9 Inhibitor II (CAS 193807-60-2)  Product Citations

See how others have used MMP-2/MMP-9 Inhibitor II (CAS 193807-60-2). Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 28959975  Venkatesh, HS.|Tam, LT.|Woo, PJ.|Lennon, J.|Nagaraja, S.|Gillespie, SM.|Ni, J.|Duveau, DY.|Morris, PJ.|Zhao, JJ.|Thomas, CJ.|Monje, M.| et al. 2017. Nature. 549: 533-537.

PMID: # 26400086  Zhou, J. et al. 2015. J. Biol. Chem. 290: 27215-27.

Citations 1 to 2 of 2 total

What type of inhidor is it?

Asked by: juliems34
Thank you for your question. This MMP-2/MMP-9 Inhibitor II is a potent inhibitor of MMP-2 and MMP-9. It as been shown to induce and rapidly activate HIF.
Answered by: Tech Service
Date published: 2019-10-21

Does it effect on other MMPs? Could you please tell me about the specificity of it?

Asked by: Matt48
Thank you for your question. The primary target is MMP-2, but it is an inhibitor of both MMP-2 (IC50 = 17 nM) and MMP-9 (IC50 = 30 nM).
Answered by: Technical Support
Date published: 2019-09-11

Is it cell-permeable or cell-impermeable?

Asked by: Jz28sail
Thank you for your question. sc-311430, MMP-2/MMP-9 Inhibitor II is not cell permeable. We suggest alternate product: sc-354093, MMP-2/MMP-9 Inhibitor V for a cell-permeable MMP-2/MMP-9 Inhibitor. (https://www.scbt.com/scbt/product/mmp-2-mmp-9-inhibitor-v-869577-53-7?requestFrom=search)
Answered by: Chemical Support 5
Date published: 2017-04-07
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Rated 5 out of 5 by from MMP MMP-2/MMP-9 Inhibitor II has been shown to induce and rapidly activate HIF and inhibit MMP-2 and MMP-9, in many articles. -SCBT Publication Review
Date published: 2015-05-31
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