MMP-2/MMP-9 Inhibitor I is a N-sulfonylamino acid derivative which inhibits type IV collagenase MMP-9 and MMP-2. Studies indicate that altering the sulfonamide moiety can greatly effects the activity of MMP-2/MMP-9 Inhibitor I. MMP-2 and MMP-9 are metalloproteinases that are produced by a variety of cells such as fibroblasts, chondrocytes, osteoblasts, neutrophils, macrophages, and tumor cells. It is known that the proteins are activated when they are cleaved by extracellular proteinases. The function of these enzymes are in the breakdown of the extracellular matrix in normal physiological processes such as embryonic development, reproduction, tissue remodeling, and metastasis.
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See how others have used MMP-2/MMP-9 Inhibitor I (CAS 193807-58-8). Click on the entry to view the PubMed entry .
PMID: # 26534964 Londino, JD. et al. 2015. J. Biol. Chem. 290: 31113-25.
PMID: # 24398929 Zhu, ZM. et al. 2014. Oncol. Rep. 31: 1489-97.
PMID: # 23479197 Dal-Pizzol, F. et al. 2013. Molecular neurobiology. 48: 62-70.
PMID: # 29312615 Oncotarget. 8: 109382-109392.
PMID: # 32445050 Dig. Dis. Sci.
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