MMP-2/MMP-9 Inhibitor I CAS: 193807-58-8
MF: C21H19NO4S
MW: 381.5
A potent MMP-2 and MMP-9 inhibitor.

MMP-2/MMP-9 Inhibitor I (CAS 193807-58-8)

MMP-2/MMP-9 Inhibitor I | CAS 193807-58-8 is rated 5.0 out of 5 by 1.
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Alternate Names: (2R)-2-[(4-Biphenylylsulfonyl)amino]-3-phenylpropionic Acid
Application: MMP-2/MMP-9 Inhibitor I is a potent MMP-2 and MMP-9 inhibitor
CAS Number: 193807-58-8
Purity: ≥98%
Molecular Weight: 381.5
Molecular Formula: C21H19NO4S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

MMP-2/MMP-9 Inhibitor I is a N-sulfonylamino acid derivative which inhibits type IV collagenase MMP-9 and MMP-2. Studies indicate that altering the sulfonamide moiety can greatly effects the activity of MMP-2/MMP-9 Inhibitor I. MMP-2 and MMP-9 are metalloproteinases that are produced by a variety of cells such as fibroblasts, chondrocytes, osteoblasts, neutrophils, macrophages, and tumor cells. It is known that the proteins are activated when they are cleaved by extracellular proteinases. The function of these enzymes are in the breakdown of the extracellular matrix in normal physiological processes such as embryonic development, reproduction, tissue remodeling, and metastasis.


References

1. Tamura, Y., et al. 1998. J. Med. Chem. 41: 640-649. PMID: 9484512

Physical State :
Solid
Solubility :
DMSO
Storage :
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
10667540
SMILES :
C1=CC=C(C=C1)C[[email protected]](C(=O)O)NS(=O)(=O)C2=CC=C(C=C2)C3=CC=CC=C3

Download SDS (MSDS)

Certificate of Analysis

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MMP-2/MMP-9 Inhibitor I (CAS 193807-58-8)  Product Citations

See how others have used MMP-2/MMP-9 Inhibitor I (CAS 193807-58-8). Click on the entry to view the PubMed entry .

Citations 1 to 5 of 5 total

PMID: # 26534964  Londino, JD. et al. 2015. J. Biol. Chem. 290: 31113-25.

PMID: # 24398929  Zhu, ZM. et al. 2014. Oncol. Rep. 31: 1489-97.

PMID: # 23479197  Dal-Pizzol, F. et al. 2013. Molecular neurobiology. 48: 62-70.

PMID: # 29312615  Oncotarget. 8: 109382-109392.

PMID: # 32445050  Dig. Dis. Sci.

Citations 1 to 5 of 5 total

Is it cell-permeable or cell-impermeable

Asked by: Jz28sail
Thank you for your question. sc-311429, MMP-2/MMP-9 Inhibitor I is not cell permeable. We suggest alternate product: sc-354093, MMP-2/MMP-9 Inhibitor V for a cell-permeable MMP-2/MMP-9 Inhibitor. (https://www.scbt.com/scbt/product/mmp-2-mmp-9-inhibitor-v-869577-53-7?requestFrom=search)
Answered by: Chemical Support 5
Date published: 2017-04-07
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Rated 5 out of 5 by from Tamura Tamura, Y. et al. (PubMed 9484512) found that the N-sulfonylamino acid derivative MMP-2/MMP-9 Inhibitor I was highly selective for MMP-2/MMP-9. -SCBT Publication Review
Date published: 2015-06-29
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