Molecular structure of MMP-2/MMP-9 Inhibitor I, CAS Number: 193807-58-8
MMP-2/MMP-9 Inhibitor I (CAS 193807-58-8)
See product citations (6)
Alternate Names:
(2R)-2-[(4-Biphenylylsulfonyl)amino]-3-phenylpropionic Acid
Application:
MMP-2/MMP-9 Inhibitor I is a potent MMP-2 and MMP-9 inhibitor
CAS Number:
193807-58-8
Purity:
≥95%
Molecular Weight:
381.5
Molecular Formula:
C21H19NO4S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
MMP-2/MMP-9 Inhibitor I is a N-sulfonylamino acid derivative which inhibits type IV collagenase MMP-9 and MMP-2. Studies indicate that altering the sulfonamide moiety can greatly effects the activity of MMP-2/MMP-9 Inhibitor I. MMP-2 and MMP-9 are metalloproteinases that are produced by a variety of cells such as fibroblasts, chondrocytes, osteoblasts, neutrophils, macrophages, and tumor cells. It is known that the proteins are activated when they are cleaved by extracellular proteinases. The function of these enzymes are in the breakdown of the extracellular matrix in normal physiological processes, such as embryonic development, reproduction, tissue remodeling, and metastasis.
MMP-2/MMP-9 Inhibitor I (CAS 193807-58-8) References
- Functional significance of MMP-2 and MMP-9 expression by human malignant oral keratinocyte cell lines. | Robinson, CM., et al. 2003. Arch Oral Biol. 48: 779-86. PMID: 14550380
- Interactions of proteases, protease inhibitors, and the beta1 integrin/laminin gamma3 protein complex in the regulation of ectoplasmic specialization dynamics in the rat testis. | Siu, MK. and Cheng, CY. 2004. Biol Reprod. 70: 945-64. PMID: 14645107
- Enhanced migration of tissue inhibitor of metalloproteinase overexpressing hepatoma cells is attributed to gelatinases: relevance to intracellular signaling pathways. | Roeb, E., et al. 2005. World J Gastroenterol. 11: 1096-104. PMID: 15754388
- Gelatinases (MMP-2 and MMP-9) are preferentially expressed by Th1 vs. Th2 cells. | Abraham, M., et al. 2005. J Neuroimmunol. 163: 157-64. PMID: 15885317
- Epidermal growth factor and transforming growth factor-beta1 enhance HK-2 cell migration through a synergistic increase of matrix metalloproteinase and sustained activation of ERK signaling pathway. | Tian, YC., et al. 2007. Exp Cell Res. 313: 2367-77. PMID: 17467690
- Matrix metalloproteinase-2 is involved in myelination of dorsal root ganglia neurons. | Lehmann, HC., et al. 2009. Glia. 57: 479-89. PMID: 18814268
- Matrix metalloproteinase-9 inhibition ameliorates pathogenesis and improves skeletal muscle regeneration in muscular dystrophy. | Li, H., et al. 2009. Hum Mol Genet. 18: 2584-98. PMID: 19401296
- Pachymic acid impairs breast cancer cell invasion by suppressing nuclear factor-κB-dependent matrix metalloproteinase-9 expression. | Ling, H., et al. 2011. Breast Cancer Res Treat. 126: 609-20. PMID: 20521099
- 6-Shogaol, an active constituent of ginger, inhibits breast cancer cell invasion by reducing matrix metalloproteinase-9 expression via blockade of nuclear factor-κB activation. | Ling, H., et al. 2010. Br J Pharmacol. 161: 1763-77. PMID: 20718733
- Tissue inhibitors of metalloproteinases are proteolytic targets of matrix metalloproteinase 9. | Coates-Park, S., et al. 2023. Matrix Biol. 123: 59-70. PMID: 37804930
- Highly selective and orally active inhibitors of type IV collagenase (MMP-9 and MMP-2): N-sulfonylamino acid derivatives. | Tamura, Y., et al. 1998. J Med Chem. 41: 640-9. PMID: 9484512
Inhibitor of:
MMP-2, and MMP-9.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MMP-2/MMP-9 Inhibitor I, 5 mg | sc-311429 | 5 mg | $338.00 |