MMP-2/MMP-3 Inhibitor I MF: C13H14N4O3S2
MW: 338.4
A potent inhibitor of MMP-2 and MMP-3.

MMP-2/MMP-3 Inhibitor I

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Alternate Names: N-[[(4,5-Dihydro-5-thioxo-1,3,4-thiadiazol-2-yl)amino]carbonyl]-L-phenylalanine Methyl Ester
Application: MMP-2/MMP-3 Inhibitor I is a potent inhibitor of MMP-2 and MMP-3
Molecular Weight: 338.4
Molecular Formula: C13H14N4O3S2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

MMP-2/MMP-3 Inhibitor I is a potent MMP-2 (gelatinase A; Ki = 17 μM) and MMP-3 (stromelysin-1; Ki = 290 nM) inhibitor.


References

1. Jacobsen, E J., et al., 1999. Synthesis of a series of stromelysin-selective thiadiazole urea matrix metalloproteinase inhibitors. Journal of medicinal chemistry. 42(9): 1525-36. PMID: 10229623

Physical State :
Solid
Solubility :
Soluble in DMSO (200 mg/ml).
Storage :
Store at -20° C
Melting Point :
249.38° C (Predicted)
Boiling Point :
578.75° C (Predicted)
Density :
1.49 g/cm3 (Predicted)
Refractive Index :
n20D 1.70 (Predicted)
Ki Data :
MMP-3: Ki= 290 nM; MMP-2: Ki= 17 µM
pK Values :
pKb: 9.21 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
16760550
MDL Number :
MFCD02683952
SMILES :
COC(=O)C(CC1=CC=CC=C1)NC(=O)NC2=NNC(=S)S2

Download SDS (MSDS)

Certificate of Analysis

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MMP-2/MMP-3 Inhibitor I  Product Citations

See how others have used MMP-2/MMP-3 Inhibitor I. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 28959975  Venkatesh, HS.|Tam, LT.|Woo, PJ.|Lennon, J.|Nagaraja, S.|Gillespie, SM.|Ni, J.|Duveau, DY.|Morris, PJ.|Zhao, JJ.|Thomas, CJ.|Monje, M.| et al. 2017. Nature. 549: 533-537.

Citations 1 to 1 of 1 total
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