Molecular structure of MMP-2 Inhibitor I, CAS Number: 10335-69-0
MMP-2 Inhibitor I (CAS 10335-69-0)
See product citations (19)
Alternate Names:
Oleoyl-N-hydroxylamide; N-Hydroxy-9-octadecenamide
Application:
MMP-2 Inhibitor I is a matrix metalloproteinase gelatinase A inhibitor
CAS Number:
10335-69-0
Purity:
≥98%
Molecular Weight:
297.48
Molecular Formula:
C18H35NO2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
MMP-2 Inhibitor I, cis-9-Octadecenoyl-N-hydroxylamide, is a small molecule non-reversible inhibitor of MMP-2 (matrix metalloproteinases gelatinase A), a protein implicated in the pathological breakdown of extracellular matrix proteins. The migration of vascular smooth muscle cells stimulated by interleukin-Ibeta requires active MMP-2, and MMP-2 Inhibitor I was shown to attenuate this migration. Migration of various normal and oncogenic cells similarly depend upon MMP-2 activity, and MMP-2 Inhibitor I has been indicated for intervention upon these migratory processes.
MMP-2 Inhibitor I (CAS 10335-69-0) References
- Involvement of fibronectin type II repeats in the efficient inhibition of gelatinases A and B by long-chain unsaturated fatty acids. | Berton, A., et al. 2001. J Biol Chem. 276: 20458-65. PMID: 11278959
- Involvement of matrix metalloproteinases in the adipose conversion of 3T3-L1 preadipocytes. | Croissandeau, G., et al. 2002. Biochem J. 364: 739-46. PMID: 12049638
- N-Myc and Bcl-2 coexpression induces MMP-2 secretion and activation in human neuroblastoma cells. | Noujaim, D., et al. 2002. Oncogene. 21: 4549-57. PMID: 12085233
- Shear stress inhibits smooth muscle cell migration via nitric oxide-mediated downregulation of matrix metalloproteinase-2 activity. | Garanich, JS., et al. 2005. Am J Physiol Heart Circ Physiol. 288: H2244-52. PMID: 15637127
- Human CC chemokine CCL23 enhances expression of matrix metalloproteinase-2 and invasion of vascular endothelial cells. | Son, KN., et al. 2006. Biochem Biophys Res Commun. 340: 498-504. PMID: 16378600
- Interleukin-lβ induces migration of rat arterial smooth muscle cells through a mechanism involving increased matrix metalloproteinase-2 activity. | Wang, Z., et al. 2011. J Surg Res. 169: 328-36. PMID: 20371087
- uPA and MMP-2 were involved in self-assembled network formation in a two dimensional co-culture model of bone marrow stromal cells and endothelial cells. | Li, H., et al. 2013. J Cell Biochem. 114: 650-7. PMID: 23059760
- Matrix metalloproteinase-2 degrades fibrillin-1 and fibrillin-2 of oxytalan fibers in the human eye and periodontal ligaments in vitro. | Kawagoe, M., et al. 2013. Acta Histochem Cytochem. 46: 153-9. PMID: 24194629
- E6/E7 oncoproteins of high risk HPV-16 upregulate MT1-MMP, MMP-2 and MMP-9 and promote the migration of cervical cancer cells. | Zhu, D., et al. 2015. Int J Clin Exp Pathol. 8: 4981-9. PMID: 26191191
- Role of Spm-Cer-S1P signalling pathway in MMP-2 mediated U46619-induced proliferation of pulmonary artery smooth muscle cells: protective role of epigallocatechin-3-gallate. | Chowdhury, A., et al. 2015. Cell Biochem Funct. 33: 463-77. PMID: 26486270
- Aurora-A modulates MMP-2 expression via AKT/NF-κB pathway in esophageal squamous cell carcinoma cells. | Wang, X., et al. 2016. Acta Biochim Biophys Sin (Shanghai). 48: 520-7. PMID: 27125974
- Increased gelatinase A (MMP-2) and cathepsin B activity in invasive tumor regions of human colon cancer samples. | Emmert-Buck, MR., et al. 1994. Am J Pathol. 145: 1285-90. PMID: 7992833
- Association of MMP-2 activation potential with metastatic progression in human breast cancer cell lines independent of MMP-2 production. | Azzam, HS., et al. 1993. J Natl Cancer Inst. 85: 1758-64. PMID: 8411260
Inhibitor of:
MMP, and MMP-2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MMP-2 Inhibitor I, 10 mg | sc-204092 | 10 mg | $167.00 |