MMP-2 Inhibitor I CAS: 10335-69-0
MF: C18H35NO2
MW: 297.48
A matrix metalloproteinase gelatinase A inhibitor.

MMP-2 Inhibitor I (CAS 10335-69-0)

MMP-2 Inhibitor I | CAS 10335-69-0 is rated 5.0 out of 5 by 1.
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Alternate Names: Oleoyl-N-hydroxylamide; N-Hydroxy-9-octadecenamide
Application: MMP-2 Inhibitor I is a matrix metalloproteinase gelatinase A inhibitor
CAS Number: 10335-69-0
Purity: ≥98%
Molecular Weight: 297.48
Molecular Formula: C18H35NO2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

MMP-2 Inhibitor I, cis-9-Octadecenoyl-N-hydroxylamide, is a small molecule reversible inhibitor of MMP-2 (matrix metalloproteinases gelatinase A), a protein implicated in the pathological breakdown of extracellular matrix proteins. The migration of vascular smooth muscle cells stimulated by interleukin-Iβ requires active MMP-2, and cis-9-Octadecenoyl-N-hydroxylamide was shown to attenuate this migration. Migration of various normal and oncogenic cells similarly depend upon MMP-2 activity, and cis-9-Octadecenoyl-N-hydroxylamide has been indicated for intervention upon these migratory processes.


References

1. Azzam, H.S., et al. 1993. J. Natl. Cancer Inst. 85: 1758-1764. PMID: 8411260
2. Emmert-Buck, M.R., et al. 1994. Am. J. Pathol. 145: 1285-1290. PMID: 7992833
3. Berton, A., et al. 2001. J. Biol. Chem. 276: 20458-20465. PMID: 11278959
4. Wang, Z., et al. 2010. J Surg Res. [Epub ahead of print]. PMID: 20371087

Physical State :
Solid
Solubility :
Soluble in DMSO (2 mg/ml), and ethanol (3 mg/ml).
Storage :
Store at -20° C
Melting Point :
183.14° C (Predicted)
Boiling Point :
463.01° C (Predicted)
Density :
~0.9 g/cm3 (Predicted)
Refractive Index :
n20D 1.47 (Predicted)
Ki Data :
MMP-2: Ki= 1.7 µM
pK Values :
pKa: 9.48 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
6436367
MDL Number :
MFCD02683956
SMILES :
CCCCCCCC/C=C\\CCCCCCCC(=O)NO

Download SDS (MSDS)

Certificate of Analysis

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MMP-2 Inhibitor I (CAS 10335-69-0)  Product Citations

See how others have used MMP-2 Inhibitor I (CAS 10335-69-0). Click on the entry to view the PubMed entry .

Citations 1 to 10 of 14 total

PMID: # 29903032  Liu, C.|Qu, L.|Zhao, C.|Shou, C.| et al. 2018. J. Exp. Clin. Cancer Res. 37: 117.

PMID: # 27210740  Chowdhury, A. et al. 2016. Arch. Biochem. Biophys. 603: 91-101.

PMID: # 26637168  Nam, HS. et al. 2015. PLoS ONE. 10: e0144218.

PMID: # 26293166  Nau, R. et al. 2015. Expert Rev Anti Infect Ther. 13: 1401-23.

PMID: # 26191191  Zhu, D. et al. 2015. International journal of clinical and experimental pathology. 8: 4981-9.

PMID: # 25588050  Guan, BZ. et al. 2015. Cell Adh Migr. 0.

PMID: # 24419461  Barichello, T. et al. 2014. Experimental biology and medicine (Maywood, N.J.). 239: 225-31.

PMID: # 23479197  Dal-Pizzol, F. et al. 2013. Molecular neurobiology. 48: 62-70.

PMID: # 24224022  Chen, R. et al. 2013. PloS one. 8: e79930.

PMID: # 22736024  Liang, L. et al. 2012. Oncol. Rep. 28: 999-1005.

Citations 1 to 10 of 14 total

Is this product cell-impermeable?

Asked by: Jz28sail
Thank you for your question. No, the product is not impermeable. sc-204092, MMP-2 Inhibitor I is a cell-permeable MMP-2 inhibitor.
Answered by: Chemical Support 5
Date published: 2017-04-07
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Rated 5 out of 5 by from Wang Wang, Z. et al. (PubMed 20371087) used the MMP-2 Inhibitor I to demonstrate that IL-l induces migration of rat arterial smooth muscle cells through a mechanism involving increased MMP-2 activity. -SCBT Publication Review
Date published: 2015-01-17
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