Molecular structure of MMP-13 Inhibitor, CAS Number: 544678-85-5
MMP-13 Inhibitor (CAS 544678-85-5)
See product citations (7)
Alternate Names:
4-N,6-N-bis[(4-fluoro-3-methylphenyl)methyl]pyrimidine-4,6-dicarboxamide
Application:
MMP-13 Inhibitor is a potent inhibitor of MMP-13 activity
CAS Number:
544678-85-5
Purity:
≥98%
Molecular Weight:
410.42
Molecular Formula:
C22H20F2N4O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
The chemical compound known as MMP-13 Inhibitor is a pyrimidine dicarboxamide that has been developed to specifically inhibit the activity of matrix metalloproteinase-13 (MMP-13), also called collagenase-3. It has been found to be highly effective at inhibiting MMP-13, with an IC50 value of 8 nM. Unlike other MMP inhibitors, MMP-13 Inhibitor targets unique pockets within the MMP-13 protein structure rather than the catalytic zinc, making it highly specific for MMP-13. Furthermore, MMP-13 Inhibitor is able to block osterix-dependent calcification of matrices in limb bud cells during endochondral ossification.
MMP-13 Inhibitor (CAS 544678-85-5) References
- Osterix regulates calcification and degradation of chondrogenic matrices through matrix metalloproteinase 13 (MMP13) expression in association with transcription factor Runx2 during endochondral ossification. | Nishimura, R., et al. 2012. J Biol Chem. 287: 33179-90. PMID: 22869368
- Matrix metalloproteinase 13 is a new contributor to skeletal muscle regeneration and critical for myoblast migration. | Lei, H., et al. 2013. Am J Physiol Cell Physiol. 305: C529-38. PMID: 23761625
- Shedding of NG2 by MMP-13 attenuates anoikis. | Joo, NE., et al. 2014. DNA Cell Biol. 33: 854-62. PMID: 25166220
- Dickkopf-3 regulates prostate epithelial cell acinar morphogenesis and prostate cancer cell invasion by limiting TGF-β-dependent activation of matrix metalloproteases. | Romero, D., et al. 2016. Carcinogenesis. 37: 18-29. PMID: 26503968
- IL-37 diminishes proteoglycan loss in human OA cartilage: donor-specific link between IL-37 and MMP-3. | van Geffen, EW., et al. 2019. Osteoarthritis Cartilage. 27: 148-157. PMID: 30201492
- Physiologic Medium Maintains the Homeostasis of Immature Bovine Articular Cartilage Explants in Long-Term Culture. | Durney, KM., et al. 2019. J Biomech Eng. 141: PMID: 30383167
- Matrix Metalloproteinase 13 Activity is Required for Normal and Hypoxia-Induced Precocious Hatching in Zebrafish Embryos. | Small, CD., et al. 2020. J Dev Biol. 8: PMID: 32023839
Inhibitor of:
Enzyme, and MMP-13.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MMP-13 Inhibitor, 1 mg | sc-205756 | 1 mg | $172.00 | |||
MMP-13 Inhibitor, 5 mg | sc-205756A | 5 mg | $630.00 |