Molecular structure of MM 77 dihydrochloride, CAS Number: 159311-94-1
MM 77 dihydrochloride (CAS 159311-94-1)
Alternate Names:
1-(2-Methoxyphenyl)-4-(4-succinimidobutyl)piperazine dihydrochloride
Application:
MM 77 dihydrochloride is a highly potent SR-1A antagonist
CAS Number:
159311-94-1
Molecular Weight:
418.36
Molecular Formula:
C19H27N3O3•2HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
Technical Information
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SDS & Certificate of Analysis
Highly potent and fairly selective 5-HT1A (postsynaptic) antagonist.
MM 77 dihydrochloride (CAS 159311-94-1) References
- Behavioural profiles in the mouse defence test battery suggest anxiolytic potential of 5-HT(1A) receptor antagonists. | Griebel, G., et al. 1999. Psychopharmacology (Berl). 144: 121-30. PMID: 10394992
- Effect of the postsynaptic 5-HT1A receptor antagonist MM-77 on stressed mice treated with 5-HT1A receptor agents. | Alfredo, BA. and Ofir, P. 2005. Eur J Pharmacol. 508: 155-8. PMID: 15680266
- A comparison of the effects of the 5HT1A antagonists MM-77 and WAY-100635 on the mouse isolated vasa deferentia. | Arkle, MJ., et al. 2005. Auton Autacoid Pharmacol. 25: 121-8. PMID: 15955032
- Delta(9)-tetrahydrocannabinol prolongs the immobility time in the mouse forced swim test: involvement of cannabinoid CB(1) receptor and serotonergic system. | Egashira, N., et al. 2008. Eur J Pharmacol. 589: 117-21. PMID: 18565508
- Cannabinoid administration increases 5HT1A receptor binding and mRNA expression in the hippocampus of adult but not adolescent rats. | Zavitsanou, K., et al. 2010. Neuroscience. 169: 315-24. PMID: 20438810
- Neonatal lipopolysaccharide treatment has long-term effects on monoaminergic and cannabinoid receptors in the rat. | Zavitsanou, K., et al. 2013. Synapse. 67: 290-9. PMID: 23389966
- Synergistic Effect between Maternal Infection and Adolescent Cannabinoid Exposure on Serotonin 5HT1A Receptor Binding in the Hippocampus: Testing the 'Two Hit' Hypothesis for the Development of Schizophrenia. | Dalton, VS., et al. 2012. ISRN Psychiatry. 2012: 451865. PMID: 23738203
- Adaptive changes in serotonin metabolism preserve normal behavior in mice with reduced TPH2 activity. | Mosienko, V., et al. 2014. Neuropharmacology. 85: 73-80. PMID: 24863038
- Alteration of transcriptional networks in the entorhinal cortex after maternal immune activation and adolescent cannabinoid exposure. | Hollins, SL., et al. 2016. Brain Behav Immun. 56: 187-96. PMID: 26923065
- Comparative analysis of pharmacological properties of xanomeline and N-desmethylclozapine in rat brain membranes. | Odagaki, Y., et al. 2016. J Psychopharmacol. 30: 896-912. PMID: 27464743
Inhibitor of:
SR-1A.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MM 77 dihydrochloride, 10 mg | sc-204090 | 10 mg | $129.00 | |||
MM 77 dihydrochloride, 50 mg | sc-204090A | 50 mg | $548.00 |