MM-142 nuclear extract: sc-2139

MM-142 nuclear extract is a specialized preparation derived from nuclear components, designed for use in biochemical and molecular biology research applications. This extract encompasses a rich array of nuclear proteins, DNA, and RNA fragments, providing a snapshot of the transcriptional landscape and nuclear signaling dynamics. Researchers utilize MM-142 nuclear extract primarily for studying transcription factor binding, chromatin structure, and gene expression regulation under various experimental conditions. The mechanism of action of MM-142 lies in its ability to serve as a concentrated source of nuclear signals and regulatory elements, which are essential for dissecting nuclear pathways and protein-DNA interactions in vitro. Notably, MM-142 is instrumental in identifying and characterizing the interactions of nuclear proteins with specific DNA motifs, thus facilitating the elucidation of transcriptional regulation mechanisms. Additionally, the extract has been employed in chromatin immunoprecipitation assays to explore protein-DNA interactions and in gel shift assays to study DNA-binding protein activities. The origin of the cell line used to produce MM-142 nuclear extract is verified to ensure consistency and reliability in experimental outcomes

MM-142 nuclear extract References:

1. Fezf1 is required for penetration of the basal lamina by olfactory axons to promote olfactory development.  |  Watanabe, Y., et al. 2009. J Comp Neurol. 515: 565-84. PMID: 19479999