Molecular structure of MLN7243, CAS Number: 1450833-55-2
MLN7243 (CAS 1450833-55-2)
Alternate Names:
TAK-243
CAS Number:
1450833-55-2
Molecular Weight:
519.5
Molecular Formula:
C19H20F3N5O5S2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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MLN7243 (CAS 1450833-55-2) References
- Varied Role of Ubiquitylation in Generating MHC Class I Peptide Ligands. | Wei, J., et al. 2017. J Immunol. 198: 3835-3845. PMID: 28363906
- Preclinical comparison of proteasome and ubiquitin E1 enzyme inhibitors in cutaneous squamous cell carcinoma: the identification of mechanisms of differential sensitivity. | McHugh, A., et al. 2018. Oncotarget. 9: 20265-20281. PMID: 29755650
- Ubiquitin-activating enzyme inhibition induces an unfolded protein response and overcomes drug resistance in myeloma. | Zhuang, J., et al. 2019. Blood. 133: 1572-1584. PMID: 30737236
- Differential Inhibition of Human and Trypanosome Ubiquitin E1S by TAK-243 Offers Possibilities for Parasite Selective Inhibitors. | Boer, DR. and Bijlmakers, MJ. 2019. Sci Rep. 9: 16195. PMID: 31700050
- The role of ubiquitination in tumorigenesis and targeted drug discovery. | Deng, L., et al. 2020. Signal Transduct Target Ther. 5: 11. PMID: 32296023
- Ubiquitin activation is essential for schizont maturation in Plasmodium falciparum blood-stage development. | Green, JL., et al. 2020. PLoS Pathog. 16: e1008640. PMID: 32569299
- Direct Conjugation of NEDD8 to the N-Terminus of a Model Protein Can Induce Degradation. | Vijayasimha, K., et al. 2021. Cells. 10: PMID: 33918652
- Ubiquitin-proteasome System Is a Promising Target for Killing Cisplatin-resistant Bladder Cancer Cells. | Okubo, K., et al. 2021. Anticancer Res. 41: 2901-2912. PMID: 34083281
- Overexpression of ABCG2 Confers Resistance to MLN7243, a Ubiquitin-Activating Enzyme (UAE) Inhibitor. | Wu, ZX., et al. 2021. Front Cell Dev Biol. 9: 697927. PMID: 34336849
- Development of decoy oligonucleotide-warheaded chimeric molecules targeting STAT3. | Shih, PC., et al. 2023. Bioorg Med Chem. 95: 117507. PMID: 37922656
Inhibitor of:
(eukaryotic translation initiation factor) eIF, (eukaryotic translation initiation factor) eIF1, (eukaryotic translation initiation factor) eIF2, (eukaryotic translation initiation factor) eIF5, APPBP2, ARL7, ASB-11, ASB-8, Cdc34, Cdc53, CLCP1, CUL-3, DDI1, E330034G19Rik, EG545802, EG546638, eIF2Bδ, eIF3ε, eIF5A1, EndoV, FBXO21, FBXO41, Gm71, Herc3, Herc4, KLHDC2, KLHL21, KLHL38, Mms2, NARS2, NCDN, NECAP 1, NEDL2, QPCTL, Ref-1, RFPL4A, RFWD3, RLIM, RNF133, RNF145, RNF17, RNF186, RNF207, RNF215, RNF26, RNF6, SCAND1, Smurf2, TMEM129, TRAC-1, Ub, UBE1, UBE1L2, UBE2U, UBE4A, Ubiquitin conjugating enzyme E2 (UBE2), UBXN2B, USP18, and ZFP91.Activator of:
BC061212, CUL-5, D5Ertd577e, EG229571, KLHL24, MARCH3, NEDD8, RNF149, RNF222, RNF38, UBC13, UBE2D4, UBE2Z, and USP17L29.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MLN7243, 5 mg | sc-507338 | 5 mg | $340.00 |