Molecular structure of ML-180, CAS Number: 863588-32-3
ML-180 (CAS 863588-32-3)
Alternate Names:
6-[4-(3-chlorophenyl)-1-piperazinyl]-3-cyclohexyl-2,4(1H,3H)-pyrimidinedione
Application:
ML-180 is an antagonist for LRH1 (NR5A2)
CAS Number:
863588-32-3
Molecular Weight:
388.9
Molecular Formula:
C20H25ClN4O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
ML-180 is an antagonist for liver receptor homolog-1 (LRH1), also known as Nuclear Receptor Subfamily 5 Group A Member 2 (NR5A2). LRH1 is a transcription factor that plays a role in various physiological processes, including liver development, bile acid metabolism, steroidogenesis, and regulation of lipid and glucose homeostasis. ML-180 is inactive at the related steroidogenic factor-1 transcriptional activator. Through LRH1, ML-180 alters the expression of haptoglobin and serum amyloid proteins A1 and A4, induces the death of estrogen-receptor negative MDA-MB-231 breast cancer cells, and inhibits the steroidogenic acute regulatory promoter.
ML-180 (CAS 863588-32-3) References
- Dynamic effect of three locking plates fixated to humeral fracture based on multibody musculoskeletal model. | Jian-Qiao Peng, M., et al. 2021. Int J Med Robot. 17: e2323. PMID: 34405530
Inhibitor of:
11β-HSD1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ML-180, 5 mg | sc-396641 | 5 mg | $141.00 | |||
ML-180, 10 mg | sc-396641A | 10 mg | $223.00 |