Molecular structure of ML 133 hydrochloride, CAS Number: 1222781-70-5
ML 133 hydrochloride (CAS 1222781-70-5)
Alternate Names:
N-[(4-Methoxyphenyl)methyl]-1-naphthalenemethanamine Hydrochloride
CAS Number:
1222781-70-5
Molecular Weight:
313.82
Molecular Formula:
C19H19NO•HCl
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
ML 133 hydrochloride, a white crystalline substance soluble in water and ethanol. It is used to study cell signaling associated with potassium channels. It can be instrumental in probing the molecular dynamics responsible for the psychoactive impacts of compounds within the benzylamine category. This compound specifically inhibits Kir2.x inwardly rectifying potassium channels, showing no impact on rKir1.1.
ML 133 hydrochloride (CAS 1222781-70-5) References
- Complex molecular and functional outcomes of single versus sequential cytokine stimulation of rat microglia. | Siddiqui, TA., et al. 2016. J Neuroinflammation. 13: 66. PMID: 27009332
- Mechanisms Underlying Interferon-γ-Induced Priming of Microglial Reactive Oxygen Species Production. | Spencer, NG., et al. 2016. PLoS One. 11: e0162497. PMID: 27598576
- Differential Kv1.3, KCa3.1, and Kir2.1 expression in 'classically' and 'alternatively' activated microglia. | Nguyen, HM., et al. 2017. Glia. 65: 106-121. PMID: 27696527
- K+ -independent Kir blockade by external Cs+ and Ba2. | Gilles, O. 2022. Physiol Rep. 10: e15200. PMID: 35274814
- Hypoxia Induces Apoptosis of Microglia BV2 by Upregulating Kir2.1 to Activate Mitochondrial-Related Apoptotic Pathways. | Xie, YF., et al. 2022. Dis Markers. 2022: 5855889. PMID: 35340413
- Oxytocin-Modulated Ion Channel Ensemble Controls Depolarization, Integration and Burst Firing in CA2 Pyramidal Neurons. | Liu, JJ., et al. 2022. J Neurosci. 42: 7707-7720. PMID: 36414006
- Persistent increase of accumbens cocaine ensemble excitability induced by IRK downregulation after withdrawal mediates the incubation of cocaine craving. | He, G., et al. 2023. Mol Psychiatry. 28: 448-462. PMID: 36481931
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ML 133 hydrochloride, 5 mg | sc-484328 | 5 mg | $84.00 |