(-)-MK 801 maleate CAS: 77086-19-2
MF: C16H15N•C4H4O4
MW: 337.37
An NMDA receptor antagonist.

(-)-MK 801 maleate (CAS 77086-19-2)

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Alternate Names: (5R,10S)-(-)-5-Methyl-10,11-dihydro -5H-dibenzo[a,d]cylcohepten-5,10-imine maleate
Application: (−)-MK 801 maleate is an NMDA receptor antagonist
CAS Number: 77086-19-2
Molecular Weight: 337.37
Molecular Formula: C16H15N•C4H4O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

(-)-MK 801 maleate is the less active enantiomer, shown to be 10-fold less potent than (+)-MK 801 maleate (sc-203137); (-)-MK 801 maleate acts as a potent, selective, and non-competitive NMDA receptor antagonist. It acts by binding to a site located within the NMDA associated ion channel.

Physical State :
Solid
Solubility :
Soluble in water (25 mM), DMSO (68 mg/ml at 25 °C), and ethanol (50 mM).
Storage :
Store at 4° C
Melting Point :
203-205° C
Refractive Index :
n20D 1.63 (Predicted)
Optical Activity :
α25/D -118°, c = 0.64 in ethanol; α25/D -117.7°, c = 1 in methanol
IC50 :
[3H]TCP binding: IC50 = 9 nM (hippocampus); N-methyl-D-aspartate-induced [3H]norepinephrine (NE) release: IC50 = 20 nM; NMDA: IC50 = 37.2 nM; Microglial TNF-α output: EC5050 = 400 µM (BV-2 cells)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
16219612
Merck Index :
14: 3386
MDL Number :
MFCD00082466
SMILES :
C[[email protected]]12C3=CC=CC=C3C[[email protected]](N1)C4=CC=CC=C24.C(=C\C(=O)O)\C(=O)O

Download SDS (MSDS)

Certificate of Analysis

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