(-)-MK 801 maleate is the less active enantiomer, shown to be 10-fold less potent than (+)-MK 801 maleate (sc-203137); (-)-MK 801 maleate acts as a potent, selective, and non-competitive NMDA receptor antagonist. It acts by binding to a site located within the NMDA associated ion channel.
Soluble in water (25 mM), DMSO (68 mg/ml at 25 °C), and ethanol (50 mM).
Store at 4° C
n20D 1.63 (Predicted)
α25/D -118°, c = 0.64 in ethanol; α25/D -117.7°, c = 1 in methanol
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