Mitomycin A (CAS 4055-39-4)
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Mitomycin A is a DNA crosslinking agent that functions by inhibiting DNA synthesis and inducing DNA damage. It forms covalent bonds with DNA, leading to the formation of interstrand crosslinks, which interfere with the replication and transcription processes. Mitomycin A′s mechanism of action involves the alkylation of guanine residues in DNA, resulting in the disruption of the double helix structure and the inhibition of DNA polymerase activity. Mitomycin A induces the production of reactive oxygen species, leading to oxidative stress and further DNA damage. These mechanisms collectively contribute to the cytotoxic effects of Mitomycin A, making it potent for studying DNA damage response and repair pathways in experimental applications.
Mitomycin A (CAS 4055-39-4) References
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- Reductive activation of mitomycin A by thiols. | Paz, MM. and Tomasz, M. 2001. Org Lett. 3: 2789-92. PMID: 11529757
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- Cardiotoxicity of mitomycin A, mitomycin C, and seven N7 analogs in vitro. | Dorr, RT., et al. 1992. Cancer Chemother Pharmacol. 31: 1-5. PMID: 1458553
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Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Mitomycin A, 2.5 mg | sc-218857 | 2.5 mg | $357.00 | |||
Mitomycin A, 5 mg | sc-218857A | 5 mg | $612.00 | |||
Mitomycin A, 10 mg | sc-218857B | 10 mg | $1122.00 | |||
Mitomycin A, 50 mg | sc-218857C | 50 mg | $4947.00 | |||
Mitomycin A, 100 mg | sc-218857D | 100 mg | $8374.00 | |||
Mitomycin A, 500 mg | sc-218857E | 500 mg | $34753.00 | |||
Mitomycin A, 1 g | sc-218857F | 1 g | $65860.00 |