Molecular structure of Misoprostol, CAS Number: 59122-46-2
Misoprostol (CAS 59122-46-2)
See product citations (2)
Alternate Names:
SC-29333
Application:
Misoprostol is a synthetic PGE that alters intracellular calcium levels
CAS Number:
59122-46-2
Purity:
99%
Molecular Weight:
382.53
Molecular Formula:
C22H38O5
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Misoprostol, a synthetic E prostaglandin, may act to prevent tissue corrosion induced by certain anti-inflammatory compounds. This E1 analog displays agonist activity at EP receptors and decreases NSAID-induced gastric ulcerations. Additionally, Misoprostol may act to have negative effects on the murine nervous system by altering the intracellular calcium levels in neuroblastoma cells. Other experiments have noted that Misoprostol has the ability to affect serum concentration of beta2-microglobulin, which is related to antigen presentation on hepatocyte surface. Misoprostol is an activator of EP1, EP2, EP3 and EP4.
Misoprostol (CAS 59122-46-2) References
- Radioprotective effect of misoprostol on mouse spermatogonial stem cells. | de Rooij, DG., et al. 1998. Genet Res. 72: 185-9. PMID: 10036973
- Effect of misoprostol on serum beta2-microglobulin in the course of viral hepatitis B. | Flisiak, R. and Prokopowicz, D. 1999. Eur J Gastroenterol Hepatol. 11: 1227-30. PMID: 10563531
- Maternal death related to misoprostol overdose. | Henriques, A., et al. 2007. Obstet Gynecol. 109: 489-90. PMID: 17267868
- Misoprostol, an anti-ulcer agent and PGE2 receptor agonist, protects against cerebral ischemia. | Li, J., et al. 2008. Neurosci Lett. 438: 210-5. PMID: 18472336
- Prostaglandin E(2) and misoprostol induce neurite retraction in Neuro-2a cells. | Tamiji, J. and Crawford, DA. 2010. Biochem Biophys Res Commun. 398: 450-6. PMID: 20599704
- Misoprostol elevates intracellular calcium in Neuro-2a cells via protein kinase A. | Tamiji, J. and Crawford, DA. 2010. Biochem Biophys Res Commun. 399: 565-70. PMID: 20678471
- Lack of evidence for neonatal misoprostol neurodevelopmental toxicity in C57BL6/J mice. | Koenig, CM., et al. 2012. PLoS One. 7: e38911. PMID: 22719983
- PGE2 receptor agonist misoprostol protects brain against intracerebral hemorrhage in mice. | Wu, H., et al. 2015. Neurobiol Aging. 36: 1439-50. PMID: 25623334
- Morphological Findings in Trophozoites during Amoebic Abscess Development in Misoprostol-Treated BALB/c Mice. | Aceves-Cano, A., et al. 2015. Biomed Res Int. 2015: 898467. PMID: 26090455
- PGE2-EP3 signaling pathway contributes to protective effects of misoprostol on cerebral injury in APP/PS1 mice. | Tian, X., et al. 2016. Oncotarget. 7: 25304-14. PMID: 27015117
- Prevention of NSAID-induced gastric ulcer with misoprostol: multicentre, double-blind, placebo-controlled trial. | Graham, DY., et al. 1988. Lancet. 2: 1277-80. PMID: 2904006
- Misoprostol regulates Bnip3 repression and alternative splicing to control cellular calcium homeostasis during hypoxic stress. | Field, JT., et al. 2018. Cell Death Discov. 4: 37. PMID: 30275982
- Misoprostol protects mice against severe Clostridium difficile infection and promotes recovery of the gut microbiota after antibiotic perturbation. | Zackular, JP., et al. 2019. Anaerobe. 58: 89-94. PMID: 31220605
- Misoprostol treatment prevents hypoxia-induced cardiac dysfunction through a 14-3-3 and PKA regulatory motif on Bnip3. | Martens, MD., et al. 2021. Cell Death Dis. 12: 1105. PMID: 34824192
- Embryotoxic effects of misoprostol in the mouse. | Paumgartten, FJ., et al. 1995. Braz J Med Biol Res. 28: 355-61. PMID: 8520532
Inhibitor of:
Gastrokine 1, and Pepsin C.Activator of:
BRAK, DP, DP2_CRTH2, EP1, EP2, EP3, EP4, FOXP1, Gastrokine 2, GPR-44, MCP-5, PGE synthase, PGF2alphaR, PGI2 synthase, Relaxin 1, and TG1019.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Misoprostol, 10 mg | sc-201264 | 10 mg | $179.00 | |||
Misoprostol, 100 mg | sc-201264A | 100 mg | $1126.00 | |||
Misoprostol, 1 g | sc-201264B | 1 g | $6941.00 |