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Mirtazapine is a potent SR-2 (pKi 8.05) and SR-3 (pKi 8.1) antagonist in addition to being a moderately potent α2 adrenoceptor (pKi 6.9) and histamine H1 receptor antagonist (pKi 9.3). Mirtazapine has been observed to inhibit α2 adrenergic autoreceptors, enhancing noradrenaline release, as well as showing weak affinity for monoamine transporters. Mirtazapine has also been documented to increase hippocampal noradrenaline and serotonin.
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