Mirtazapine CAS: 85650-52-8
MF: C17H19N3
MW: 265.36
A potent SR-2, SR-3, and Histamine H1 receptor antagonist.

Mirtazapine (CAS 85650-52-8)

Mirtazapine | CAS 85650-52-8 is rated 5.0 out of 5 by 1.
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Synonym: Remeron; 6-azamianserin; 1,2,3,4,10,14b-Hexahydro-2-methylpyrazino[2,1-a]pyrido[2,3-c][2]benzazepine
Application: A potent SR-2, SR-3, and Histamine H1 receptor antagonist
CAS Number: 85650-52-8
Purity: ≥98%
Molecular Weight: 265.36
Molecular Formula: C17H19N3
* Refer to Certificate of Analysis for lot specific data (including water content).
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Mirtazapine is a potent SR-2 (pKi 8.05) and SR-3 (pKi 8.1) antagonist in addition to being a moderately potent α2 adrenoceptor (pKi 6.9) and histamine H1 receptor antagonist (pKi 9.3). Mirtazapine has been observed to inhibit α2 adrenergic autoreceptors, enhancing noradrenaline release, as well as showing weak affinity for monoamine transporters. Mirtazapine has also been documented to increase hippocampal noradrenaline and serotonin.


References

1. de Boer, T.H., et al. 1988.Neuropharmacology. 27: 399-408. PMID: 3419539
2. Kooyman, A.R., et al. 1994. Neuropharmacology. 33: 501-507. PMID: 7984289
3. de Boer, T.H., et al. 1996. J. Pharmacol.Exp. Ther. 277: 852-860. PMID: 8627567

Physical State :
Solid
Solubility :
Soluble to 50 mM in Ethanol and to 20 mM in DMSO
Storage :
Store at room temperature
Melting Point :
114-116° C
Boiling Point :
~432.4° C at 760 mmHg (Predicted)
Density :
~1.2 g/cm3 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
4205
MDL Number :
MFCD00865427
SMILES :
CN1CCN2C(C1)C3=CC=CC=C3CC4=C2N=CC=C4

Download SDS (MSDS)

Certificate of Analysis

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Is this the free base form of the chemical?

Asked by: Superlativeguy
Thank you for your question. Yes this is the free base. If you have any further questions, please don't hesitate to contact us again!
Answered by: Tech Service
Date published: 2017-06-14
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Rated 5 out of 5 by from De Boer et al De Boer et al. (PubMed ID 8627567) found that mirtazapine had alpha-2 adrenoreceptor antagonist properties and increased 5-HT levels in freely moving rats. -SCBT Publication Review
Date published: 2015-07-04
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