Molecular structure of Mirtazapine, CAS Number: 85650-52-8
Mirtazapine (CAS 85650-52-8)
Alternate Names:
Remeron; 6-azamianserin; 1,2,3,4,10,14b-Hexahydro-2-methylpyrazino[2,1-a]pyrido[2,3-c][2]benzazepine
Application:
Mirtazapine is a potent SR-2, SR-3, and Histamine H1 receptor antagonist
CAS Number:
85650-52-8
Purity:
≥98%
Molecular Weight:
265.36
Molecular Formula:
C17H19N3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Mirtazapine is a potent SR-2 (pKi 8.05) and SR-3 (pKi 8.1) antagonist in addition to being a moderately potent AR (alpha2 adrenoceptor) (pKi 6.9) and histamine H1 receptor antagonist (pKi 9.3). Mirtazapine has been observed to inhibit alpha2 adrenergic autoreceptors, enhancing noradrenaline release, as well as showing weak affinity for monoamine transporters. Mirtazapine has also been documented to increase hippocampal noradrenaline and serotonin. Mirtazapine is an inhibitor of SR-2A and SR-2C.
Mirtazapine (CAS 85650-52-8) References
- Mirtazapine, and mirtazapine-like compounds as possible pharmacotherapy for substance abuse disorders: evidence from the bench and the bedside. | Graves, SM., et al. 2012. Pharmacol Ther. 136: 343-53. PMID: 22960395
- Mirtazapine attenuates nicotine-seeking behavior in rats. | Barbosa-Méndez, S. and Salazar-Juárez, A. 2018. J Psychopharmacol. 32: 1010-1017. PMID: 29587564
- Mirtazapine and Weight Gain in Avoidant and Restrictive Food Intake Disorder. | Gray, E., et al. 2018. J Am Acad Child Adolesc Psychiatry. 57: 288-289. PMID: 29588055
- Mirtazapine suppresses sterile inflammation through NLRP3-inflammasome in diabetic rat kidney. | Sahin, E., et al. 2019. Acta Histochem. 121: 289-296. PMID: 30711241
- Optimal dose of selective serotonin reuptake inhibitors, venlafaxine, and mirtazapine in major depression: a systematic review and dose-response meta-analysis. | Furukawa, TA., et al. 2019. Lancet Psychiatry. 6: 601-609. PMID: 31178367
- Neurochemical and autonomic pharmacological profiles of the 6-aza-analogue of mianserin, Org 3770 and its enantiomers. | de Boer, TH., et al. 1988. Neuropharmacology. 27: 399-408. PMID: 3419539
- Mirtazapine-induced decrease in cocaine sensitization is enhanced by environmental enrichment in rats. | Barbosa-Méndez, S., et al. 2021. Pharmacol Biochem Behav. 208: 173237. PMID: 34274360
- Mirtazapine prevents cell activation, inflammation, and oxidative stress against isoflurane exposure in microglia. | Wang, Q., et al. 2022. Bioengineered. 13: 521-530. PMID: 34964706
- Mirtazapine for the treatment of amphetamine and methamphetamine use disorder: A systematic review and meta-analysis. | Naji, L., et al. 2022. Drug Alcohol Depend. 232: 109295. PMID: 35066460
- The protective effects of Mirtazapine against lipopolysaccharide (LPS)-induced brain vascular hyperpermeability. | Pu, Y., et al. 2022. Bioengineered. 13: 3680-3693. PMID: 35081868
- Interaction between enantiomers of mianserin and ORG3770 at 5-HT3 receptors in cultured mouse neuroblastoma cells. | Kooyman, AR., et al. 1994. Neuropharmacology. 33: 501-7. PMID: 7984289
- Differences in modulation of noradrenergic and serotonergic transmission by the alpha-2 adrenoceptor antagonists, mirtazapine, mianserin and idazoxan. | de Boer, TH., et al. 1996. J Pharmacol Exp Ther. 277: 852-60. PMID: 8627567
Inhibitor of:
AR, Histamine H1 Receptor, SR-2A, and SR-2C.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Mirtazapine, 10 mg | sc-204088 | 10 mg | $112.00 | |||
Mirtazapine, 50 mg | sc-204088A | 50 mg | $422.00 |