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Mirabegron (CAS 223673-61-8) - chemical structure image
Molecular structure of Mirabegron, CAS Number: 223673-61-8
Mirabegron (CAS 223673-61-8) - chemical structure image
Molecular structure of Mirabegron, CAS Number: 223673-61-8
Molecular structure of Mirabegron, CAS Number: 223673-61-8

Mirabegron (CAS 223673-61-8)

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Alternate Names:
2-Amino-N-[4-[2-[[(2R)-2-hydroxy-2-phenylethyl]amino]ethyl]phenyl]-4-thiazoleacetamide
Application:
Mirabegron is a β3-AR (β3 adrenergic receptor) agonist of bladder muscles
CAS Number:
223673-61-8
Molecular Weight:
396.51
Molecular Formula:
C21H24N4O2S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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SDS & Certificate of Analysis

Mirabegron is a compound of interest in pharmacological research, where it is studied for its action as a selective beta-3 adrenergic agonist. Research applications often focus on its mechanism of action, which involves the activation of beta-3 adrenergic receptors leading to the relaxation of the detrusor smooth muscle in the urinary bladder. This mechanism is significant in the study of urinary bladder function and the regulation of detrusor muscle contractility. Moreover, investigations into Mirabegron include exploring its effects on metabolic rates and energy expenditure, as beta-3 receptors are known to be involved in the regulation of lipolysis and thermogenesis.

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA

LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences


Mirabegron (CAS 223673-61-8) References

  1. Mirabegron in the treatment of overactive bladder.  |  Leone Roberti Maggiore, U., et al. 2014. Expert Opin Pharmacother. 15: 873-87. PMID: 24646053
  2. Efficacy and Tolerability of Mirabegron Compared with Antimuscarinic Monotherapy or Combination Therapies for Overactive Bladder: A Systematic Review and Network Meta-analysis.  |  Kelleher, C., et al. 2018. Eur Urol. 74: 324-333. PMID: 29699858
  3. Mirabegron, A Selective β3-Adrenoceptor Agonist Causes an Improvement in Erectile Dysfunction in Diabetic Rats.  |  Yilmaz-Oral, D., et al. 2021. Exp Clin Endocrinol Diabetes. 129: 296-302. PMID: 30978726
  4. Mirabegron causes vesical and urethral relaxation in rats with spinal cord injury.  |  Sugaya, K., et al. 2020. Low Urin Tract Symptoms. 12: 92-98. PMID: 31389202
  5. The use of mirabegron in neurogenic bladder: a systematic review.  |  El Helou, E., et al. 2020. World J Urol. 38: 2435-2442. PMID: 31802206
  6. Effects of mirabegron on JJ stent-related symptoms: A multicentric study.  |  Cinar, O., et al. 2021. Int J Clin Pract. 75: e13857. PMID: 33230894
  7. Does mirabegron deteriorate spermatogenesis? A lesson from spinal cord injury cases.  |  Okada, H., et al. 2021. Low Urin Tract Symptoms. 13: 435-439. PMID: 33929086
  8. Mirabegron Ameliorated Atherosclerosis of ApoE-/- Mice in Chronic Intermittent Hypoxia but Not in Normoxia.  |  Wang, Y., et al. 2022. Cardiovasc Drugs Ther. 36: 805-815. PMID: 34152510
  9. Efficacy of Vibegron and Mirabegron for Overactive Bladder: A Systematic Literature Review and Indirect Treatment Comparison.  |  Kennelly, MJ., et al. 2021. Adv Ther. 38: 5452-5464. PMID: 34537953
  10. Effects of mirabegron on depression, anxiety, learning and memory in mice.  |  Tanyeri, MH., et al. 2021. An Acad Bras Cienc. 93: e20210638. PMID: 34878051
  11. Overactive bladder medication: Anticholinergics versus mirabegron by specialty.  |  Sripad, AA., et al. 2022. Urologia. 89: 511-516. PMID: 35195050
  12. Mirabegron attenuates porcine ureteral contractility via α1-adrenoceptor antagonism.  |  Lim, I. and Chess-Williams, R. 2022. Naunyn Schmiedebergs Arch Pharmacol. 395: 839-847. PMID: 35445849
  13. Mirabegron relaxes arteries from human visceral adipose tissue through antagonism of α1-adrenergic receptors.  |  De Stefano, A., et al. 2022. Vascul Pharmacol. 146: 107094. PMID: 35934296
  14. Cost-effectiveness evaluation of mirabegron versus anti-muscarinics and third-line therapies: a systematic review.  |  Mohammadnezhad, G., et al. 2022. Expert Rev Pharmacoecon Outcomes Res. 22: 1187-1198. PMID: 36172806

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Mirabegron, 500 mg

sc-211912
500 mg
$357.00

How is this product supplied. Is it a lyophilized powder? Mirabegron

Asked by: Greg
Thank you for your question. Mirabegron is not a lyophilized powder.
Answered by: BlakeJ
Date published: 2025-03-31

How to dissolve Mirabegron? Thanks!

Asked by: JIEGEN
Thank you for your question. DMSO : 79 mg/mL ( (199.23 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.) Ethanol : 8 mg/mL Water : Insoluble
Answered by: BlakeJ
Date published: 2025-03-27

The material you sell can be used as a reference standard? I mean is it traceable to a primary source?

Asked by: L Salazar
Thank you for your question. It would be helpful if you could call us, allowing for a more interactive discussion of this and other related questions.
Answered by: Technical Support
Date published: 2021-07-22

What is the solubility of this compound?

Asked by: two2igm05
The solvents of this compound are chloroform and methanol (~5 mg/mL).
Answered by: Chemical Support 4
Date published: 2017-02-28

The product is stored at 4° C for about a year, is the material still useable at this point?

Asked by: two2igm05
Thank you for your question. We recommend our customers to store this chemical at -20° C and we cannot guarantee the quality of the material if the chemical is not stored at what we suggest. If you have any further questions or concerns, please contact our Technical Service department by calling 800-457-3801 option 2, emailing scbt@scbt.com, or using the Live Chat function on our website.
Answered by: Tech Service 8
Date published: 2016-12-28
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Rated 5 out of 5 by from Incontinence urinary after prostatic surgeryIs my first time, I need information is very important
Date published: 2024-10-15
Rated 5 out of 5 by from Got rid of pain when urinationGreat product since I took for pain after syrgery.
Date published: 2024-01-12
Rated 5 out of 5 by from YunoYuno, K. et al. (PubMed 24849685) investigated the effect of Mirabegron on plasma gonadotropic and steroidal hormone levels in rats after two weeks of oral administration. They found that Mirabegron has no effect on gonadotropic or sex steroidal hormone levels -SCBT Publication Review
Date published: 2015-04-15
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Mirabegron is rated 5.0 out of 5 by 3.
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