MIRA-1 (CAS 72835-26-8)

MIRA-1, scientifically known as 1-[(1-Oxopropoxy)methyl]-1H-pyrrole 2,5-dione, is an organic compound extensively employed in scientific research due to its diverse range of applications. This compound is derived from pyrrole, a five-membered heterocyclic compound, and consists of a propionate group and a 2,5-dioxopyrrolidine ring with a methyl group attached. Its versatility has led to its utilization in various scientific research investigations, uncovering its manifold biochemical and physiological effects. Numerous studies have explored the effects of MIRA-1 on cellular processes such as cell proliferation and apoptosis. Additionally, investigations have focused on assessing the compound′s impact on biochemical and physiological phenomena like inflammation and oxidative stress. MIRA-1 has shown potential in modulating these processes. MIRA-1 exhibits the ability to reinstate the native structure, functionality, and DNA binding capacity of mutant p53. It triggers p53-mediated transcriptional activation of critical targets such as p21, MDM2, and PUMA. In vitro experiments have demonstrated that MIRA-1 elicits apoptosis in tumor cells, specifically in a mutant p53-dependent manner, with an observed IC50 value of 10μM. The exact mechanism of action underlying MIRA-1′s effects is not yet fully elucidated. However, it is postulated to function as an antioxidant, effectively scavenging reactive oxygen species, and as an anti-inflammatory agent, inhibiting the production of pro-inflammatory cytokines. These actions contribute to its potential benefits in various biological applications.