MIP-5 Antibody (A-12): sc-398069

MIP-5 Antibody (A-12) is a mouse monoclonal IgM antibody that detects MIP-5 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). MIP-5 (A-12) antibody is available as the non-conjugated form. MIP-5, also known as HCC-2, is a member of the C-C chemokine subfamily, which plays a crucial role in the immune response by acting as a chemoattractant for monocytes and T cells. MIP-5 is primarily expressed in the gut and liver, highlighting its importance in local immune responses and inflammation within these tissues. The structure of MIP-5, characterized by two adjacent cysteine residues, is essential for function, as these allow for the formation of disulfide bonds that stabilize MIP-5 and facilitate interaction with specific receptors on target cells. This structural integrity enables effective signaling and recruitment of immune cells, making MIP-5 a key player in the regulation of inflammatory processes.

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MIP-5 Antibody (A-12) References:

1. Mitogenic activation of human T cells induces two closely related genes which share structural similarities with a new family of secreted factors.  |  Zipfel, PF., et al. 1989. J Immunol. 142: 1582-90. PMID: 2521882
2. Actions of the chemotactic cytokines MCP-1, MCP-2, MCP-3, RANTES, MIP-1 alpha and MIP-1 beta on human monocytes.  |  Uguccioni, M., et al. 1995. Eur J Immunol. 25: 64-8. PMID: 7531149
3. Human macrophage inflammatory protein alpha (MIP-1 alpha) and MIP-1 beta chemokines attract distinct populations of lymphocytes.  |  Schall, TJ., et al. 1993. J Exp Med. 177: 1821-6. PMID: 7684437
4. Genomic cloning and promoter analysis of macrophage inflammatory protein (MIP)-2, MIP-1 alpha, and MIP-1 beta, members of the chemokine superfamily of proinflammatory cytokines.  |  Widmer, U., et al. 1993. J Immunol. 150: 4996-5012. PMID: 8496601
5. Identification of RANTES, MIP-1 alpha, and MIP-1 beta as the major HIV-suppressive factors produced by CD8+ T cells.  |  Cocchi, F., et al. 1995. Science. 270: 1811-5. PMID: 8525373
6. The role of MIP-1 alpha in inflammation and hematopoiesis.  |  Cook, DN. 1996. J Leukoc Biol. 59: 61-6. PMID: 8558069
7. Beta chemokines costimulate lymphocyte cytolysis, proliferation, and lymphokine production.  |  Taub, DD., et al. 1996. J Leukoc Biol. 59: 81-9. PMID: 8558072

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-MIP-5 Antibody (A-12) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-MIP-5 Antibody (A-12) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

MIP-5 Antibody (A-12) Specifications

Alternate Product Name: MIP-5

Product Clone Name: A-12

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 81-112

Epitope Target: MIP-5

Epitope Species: human

Product Reactivity/Detection: MIP-5

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for MIP-5 Antibody (A-12): P: Blocking Peptide