MIP-1γ Antibody (X-18): sc-74228

MIP-1γ Antibody (X-18) is a rat monoclonal IgG1 antibody that detects MIP-1 gamma protein of mouse and rat origin by western blotting (WB) and enzyme-linked immunosorbent assay (ELISA). Anti-MIP-1 gamma antibody (X-18) is available as a non-conjugated format, providing researchers with a reliable tool for studying this important chemokine. MIP-1γ, a member of the C-C chemokine subfamily, plays a crucial role in the immune response by acting as a chemoattractant and activator for monocytes and T cells, which are essential for inflammation and tissue repair. Notably, MIP-1γ is predominantly expressed in osteoclasts, where MIP-1γ is involved in stimulating cytoplasmic motility and polarization through the chemokine receptor CKR-1. This function is particularly significant as MIP-1γ may influence the survival and differentiation of osteoclasts, thereby regulating bone resorption, a critical process in maintaining bone health and homeostasis. The expression of MIP-1γ in osteoclasts is induced by receptor activator of nuclear factor kappa-Β ligand (RANKL), highlighting MIP-1γ′s role in bone remodeling and the potential implications for conditions such as osteoporosis and other bone-related diseases.

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MIP-1γ Antibody (X-18) References:

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