Molecular structure of Milnacipran hydrochloride, CAS Number: 101152-94-7
Milnacipran hydrochloride (CAS 101152-94-7)
See product citations (4)
Alternate Names:
(1R,2S)-rel-2-(Aminomethyl)-N,N-diethyl-1-phenylcyclopropanecarboxamide monohydrochloride; cis-2-(Aminomethyl)-N,N-diethyl-1-phenylcyclopropanecarboxamide hydrochloride
Application:
Milnacipran hydrochloride is an ST and SLC6A2 inhibitor
CAS Number:
101152-94-7
Purity:
≥99%
Molecular Weight:
282.81
Molecular Formula:
C15H22N2O•HCl
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Milnacipran hydrochloride is a serotonin-norepinephrine reuptake inhibitor that functions by inhibiting the reuptake of both serotonin and norepinephrine in the central nervous system. Milnacipran Hydrochloride′s mechanism of action involves binding to the serotonin and norepinephrine transporters, thereby preventing the reuptake of these neurotransmitters into presynaptic neurons. By doing so, it increases the levels of serotonin and norepinephrine in the synaptic cleft, leading to enhanced neurotransmission. This mechanism of action ultimately results in the modulation of neuronal activity and the regulation of mood, which may have implications in various experimental applications. Milnacipran hydrochloride′s function in inhibiting the reuptake of these neurotransmitters may contribute to its potential impact on neuronal signaling pathways and synaptic transmission.
Milnacipran hydrochloride (CAS 101152-94-7) References
- Pharmacological effects of milnacipran, a new antidepressant, given repeatedly on the alpha1-adrenergic and serotonergic 5-HT2A systems. | Maj, J., et al. 2000. J Neural Transm (Vienna). 107: 1345-59. PMID: 11145008
- An investigation of monoamine receptors involved in antinociceptive effects of antidepressants. | Yokogawa, F., et al. 2002. Anesth Analg. 95: 163-8, table of contents. PMID: 12088962
- Piloerection induced by replacing fluvoxamine with milnacipran. | Hori, S., et al. 2007. Br J Clin Pharmacol. 63: 665-71. PMID: 17324248
- Effects of milnacipran and paroxetine on overactive bladder due to neurologic diseases: a urodynamic assessment. | Sakakibara, R., et al. 2008. Urol Int. 81: 335-9. PMID: 18931554
- Milnacipran hydrochloride: its efficacy, safety and tolerability profile in fibromyalgia syndrome. | Owen, RT. 2008. Drugs Today (Barc). 44: 653-60. PMID: 19137120
- New drugs: milnacipran hydrochloride, fesoterodine fumarate, and silodosin. | Hussar, DA. 2009. J Am Pharm Assoc (2003). 49: 347-50. PMID: 19289354
- Opposite effects of milnacipran, a serotonin norepinephrine reuptake inhibitor, on the levels of nitric oxide and brain-derived neurotrophic factor in mouse brain cortex. | Ikenouchi-Sugita, A., et al. 2009. Naunyn Schmiedebergs Arch Pharmacol. 380: 479-86. PMID: 19894036
- Intranasal administration of milnacipran in rats: evaluation of the transport of drugs to the systemic circulation and central nervous system and the pharmacological effect. | Uchida, M., et al. 2011. Biol Pharm Bull. 34: 740-7. PMID: 21532166
- Rapid quantitative determination of related substances and degradants in milnacipran. | Pydimarry, SP., et al. 2014. J Chromatogr Sci. 52: 42-51. PMID: 23258392
- An experimental ninhydrin design approach for the sensitive spectrofluorimetric assay of milnacipran in human urine and plasma. | Mostafa, IM., et al. 2018. Spectrochim Acta A Mol Biomol Spectrosc. 205: 292-297. PMID: 30029192
- Biochemical profile of midalcipran (F 2207), 1-phenyl-1-diethyl-aminocarbonyl-2-aminomethyl-cyclopropane (Z) hydrochloride, a potential fourth generation antidepressant drug. | Moret, C., et al. 1985. Neuropharmacology. 24: 1211-9. PMID: 3005901
- A new sensitive approach for spectrofluorimetric assay of Milnacipran and Amisulpride in real plasma and pharmaceutical preparations via complexation with Eosin Y dye. | Atia, NN., et al. 2019. Spectrochim Acta A Mol Biomol Spectrosc. 214: 399-406. PMID: 30802797
- In Vivo Evaluation of a Novel Chitosan-Polycaprolactone Based Mucoadhesive Gastro-Retentive Sustained Release Drug Delivery System for Milnacipran HCl. | Hussain, T., et al. 2020. AAPS PharmSciTech. 21: 58. PMID: 31912249
- Nonopioid drugs for pain. | . 2022. Med Lett Drugs Ther. 64: 33-40. PMID: 35231019
- Utility of the chromogenic and fluorogenic properties of benzofurazan for the assay of milnacipran in human urine and plasma. | Mostafa, IM., et al. 2018. RSC Adv. 8: 22154-22160. PMID: 35541746
Inhibitor of:
SLC6A2, and ST.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Milnacipran hydrochloride, 10 mg | sc-204086 | 10 mg | $105.00 | |||
Milnacipran hydrochloride, 50 mg | sc-204086A | 50 mg | $446.00 |