Microtubule Marker Antibody (AE-8): sc-73551

Microtubule Marker Antibody (AE-8) is a mouse monoclonal IgM antibody that detects the Microtubule Marker protein of human origin by immunofluorescence (IF) and immunohistochemistry with paraffin-embedded sections (IHCP). Microtubule Marker (AE-8) antibody is available as the non-conjugated form. Microtubules, which are essential components of the cytoskeleton, play a critical role in maintaining cell shape and facilitating intracellular transport. These dynamic structures are composed of tubulin dimers that polymerize to form long, hollow tubes with a diameter of approximately 24 nm and can extend several micrometers to millimeters, particularly in the axons of nerve cells. The ability of microtubules to rapidly grow and shrink is vital for various cellular processes, including mitosis, where they form the mitotic spindle that segregates chromosomes during cell division. Additionally, microtubules are integral to the formation of cilia and flagella, which are crucial for cell motility and fluid movement across cell surfaces. The interaction of microtubules with motor proteins, such as kinesins and dyneins, enables the transport of cellular cargo, thereby influencing numerous physiological functions. Microtubule Marker (AE-8) monoclonal antibody serves as an invaluable tool for studying the dynamics and organization of these structures, as well as their involvement in various cellular processes and diseases.

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Microtubule Marker Antibody (AE-8) References:

1. Microtubule dynamics in the budding yeast mating pathway.  |  Molk, JN. and Bloom, K. 2006. J Cell Sci. 119: 3485-90. PMID: 16931596
2. Microtubule motors at the intersection of trafficking and transport.  |  Caviston, JP. and Holzbaur, EL. 2006. Trends Cell Biol. 16: 530-7. PMID: 16938456
3. Mitochondrial distribution and microtubule organization in fertilized and cloned porcine embryos: implications for developmental potential.  |  Katayama, M., et al. 2006. Dev Biol. 299: 206-20. PMID: 16945363
4. [Study on the influence of hypoxia induced microtubule damage on the opening of mitochondrial permeable transition pore of cardiac myocytes in rat].  |  Zheng, J., et al. 2006. Zhonghua Shao Shang Za Zhi. 22: 195-8. PMID: 16964647
5. Reversible switching of microtubule motility using thermoresponsive polymer surfaces.  |  Ionov, L., et al. 2006. Nano Lett. 6: 1982-7. PMID: 16968012
6. Microtubule mechanics: a little flexibility goes a long way.  |  McGrath, JL. 2006. Curr Biol. 16: R800-2. PMID: 16979547
7. Microtubule-targeting agents inhibit angiogenesis at subtoxic concentrations, a process associated with inhibition of Rac1 and Cdc42 activity and changes in the endothelial cytoskeleton.  |  Bijman, MN., et al. 2006. Mol Cancer Ther. 5: 2348-57. PMID: 16985069
8. Heterotypic complex formation between subunits of microtubule-associated proteins 1A and 1B is due to interaction of conserved domains.  |  Noiges, R., et al. 2006. Biochim Biophys Acta. 1763: 1011-6. PMID: 16996626
9. Self-organization of interphase microtubule arrays in fission yeast.  |  Carazo-Salas, RE. and Nurse, P. 2006. Nat Cell Biol. 8: 1102-7. PMID: 16998477

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Microtubule Marker Antibody (AE-8) has 4 citations in a variety of scientific publications.

Primary antibodies like Anti-Microtubule Marker Antibody (AE-8) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Microtubule Marker Antibody (AE-8) Specifications

Alternate Product Name: Microtubule Marker

Product Clone Name: AE-8

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM

Amino Acids:

Epitope Target: Microtubule Marker

Epitope Species: human

Product Reactivity/Detection: an antigen associated with cytoplasmic microtubules

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: IF, IHC(P)

Vialing Information: Each vial contains 100 µg IgM in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 4 citations in various scientific publications

Available Conjugates/Forms for Microtubule Marker Antibody (AE-8): N/A