MIBP1 Antibody (2418C2a): sc-130637
- MIBP1 Antibody (2418C2a) is a mouse monoclonal IgG1 MIBP1 antibody provided at 100 µg/ml
- raised against a recombinant protein corresponding to the C-terminus of MIBP1 of human origin
- recommended for detection of MIBP1 of human origin by WB and IP
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for MIBP1 Antibody (2418C2a). This work is in progress.
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MIBP1 Antibody (2418C2a) is a mouse monoclonal IgG1 antibody that detects MIBP1 protein of human origin by western blotting (WB) and immunoprecipitation (IP). Anti-MIBP1 antibody (2418C2a) is available as a non-conjugated format. MIBP1, also known as c-myc intron 1 binding protein, previously referred to as MBP-2 and HIV-EP2, is a crucial nuclear protein characterized by two zinc-finger regions, a nuclear translocation signal, and an acidic region. MIBP1 is predominantly expressed in both embryonic and adult brain and skeletal muscle, highlighting its significance in various physiological processes. MIBP1 plays a vital role in gene regulation by binding specifically to the SSTR-2 (somatostatin hormone receptor) promoter through the TC box, which is essential for enhancing promoter activity. MIBP1 interaction with the SSTR-2 promoter activates transcription, thereby influencing SSTR-2 expression, which is critical for regulating adenohypophyseal release of hormones such as growth hormone, thyroid-stimulating hormone, and prolactin. These hormones are integral to numerous cognitive and vegetative functions, indicating MIBP1 may be pivotal in the development and function of nervous and neuroendocrine tissues. MIBP1′s ability to modulate transcriptional activity underscores its potential importance in both normal physiology and disease states, making MIBP1 a valuable target for research in neurobiology and endocrinology.
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MIBP1 Antibody (2418C2a) References:
- Activation of somatostatin receptor II expression by transcription factors MIBP1 and SEF-2 in the murine brain. | Dörflinger, U., et al. 1999. Mol Cell Biol. 19: 3736-47. PMID: 10207097
- Transient expression of somatostatin peptide is a widespread feature of developing sensory and sympathetic neurons in the embryonic rat. | Katz, DM., et al. 1992. J Neurobiol. 23: 855-70. PMID: 1359005
- Structure and expression of major histocompatibility complex-binding protein 2, a 275-kDa zinc finger protein that binds to an enhancer of major histocompatibility complex class I genes. | van 't Veer, LJ., et al. 1992. Proc Natl Acad Sci U S A. 89: 8971-5. PMID: 1409593
- Cloning and characterization of a c-myc intron binding protein (MIBP1). | Makino, R., et al. 1994. Nucleic Acids Res. 22: 5679-85. PMID: 7838722
- The neurobiology of somatostatin. | Epelbaum, J., et al. 1994. Crit Rev Neurobiol. 8: 25-44. PMID: 7907281
- Differential expression of messenger RNAs for somatostatin receptor subtypes SSTR1, SSTR2 and SSTR3 in adult rat brain: analysis by RNA blotting and in situ hybridization histochemistry. | Kong, H., et al. 1994. Neuroscience. 59: 175-84. PMID: 8190266
- Somatostatin-induced contraction of human isolated saphenous vein involves sst2 receptor-mediated activation of L-type calcium channels. | Dimech, J., et al. 1995. J Cardiovasc Pharmacol. 26: 721-8. PMID: 8637186
- Growth hormone-releasing hormone neurons in the arcuate nucleus express both Sst1 and Sst2 somatostatin receptor genes. | Tannenbaum, GS., et al. 1998. Endocrinology. 139: 1450-3. PMID: 9492082
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MIBP1 Antibody (2418C2a) | sc-130637 | 100 µg/ml | $339.00 |