Mi2-β Antibody (SW-88): sc-134386
- Mi2-β Antibody (SW-88) is a mouse monoclonal IgG2a κ provided at 50 µg/0.5 ml
- raised against recombinant Mi2-β protein of human origin
- recommended for detection of Mi2-β of human origin by WB, IP, IF, IHC(P) and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Mi2-β Antibody (SW-88). This work is in progress.
Mi2-β Antibody (SW-88) is a mouse monoclonal IgG2a antibody that detects Mi2-β in human samples through western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Mi2-β (SW-88) monoclonal antibody recognizes a crucial component of the mSin3 corepressor complex, which plays a significant role in gene expression regulation by mediating histone deacetylation. Mi2-β (SW-88) antibody targets a protein primarily located in the nucleus, where Mi2-β interacts with other proteins to remodel chromatin structure, thereby influencing transcriptional activity. Anti-Mi2-β antibody (SW-88) helps researchers study how Mi2-β recruits histone deacetylases, such as HDAC1 and HDAC2, which is vital for maintaining the balance between gene activation and repression, making Mi2-β essential for proper cellular function and development. Dysregulation of Mi2-β and associated complexes can lead to various diseases, including cancer, highlighting the importance of studying Mi2-β in understanding transcriptional regulation and disease implications. Mi2-β (SW-88) monoclonal antibody provides a reliable tool for researchers investigating the intricate mechanisms of gene regulation and chromatin dynamics.
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Mi2-β Antibody (SW-88) References:
- NuRD complex component Mi-2beta binds to and represses RORgamma-mediated transcriptional activation. | Johnson, DR., et al. 2004. Biochem Biophys Res Commun. 318: 714-8. PMID: 15144897
- The chromatin remodeler Mi-2beta is required for CD4 expression and T cell development. | Williams, CJ., et al. 2004. Immunity. 20: 719-33. PMID: 15189737
- Antagonistic interactions between Ikaros and the chromatin remodeler Mi-2beta determine silencer activity and Cd4 gene expression. | Naito, T., et al. 2007. Immunity. 27: 723-34. PMID: 17980631
- The role of the chromatin remodeler Mi-2beta in hematopoietic stem cell self-renewal and multilineage differentiation. | Yoshida, T., et al. 2008. Genes Dev. 22: 1174-89. PMID: 18451107
- Mi2beta shows chromatin enzyme specificity by erasing a DNase I-hypersensitive site established by ACF. | Ishii, H., et al. 2009. J Biol Chem. 284: 7533-41. PMID: 19158090
- Mi2β-mediated silencing of the fetal γ-globin gene in adult erythroid cells. | Amaya, M., et al. 2013. Blood. 121: 3493-501. PMID: 23444401
- O-Linked N-Acetylglucosamine (O-GlcNAc) Transferase and O-GlcNAcase Interact with Mi2β Protein at the Aγ-Globin Promoter. | Zhang, Z., et al. 2016. J Biol Chem. 291: 15628-40. PMID: 27231347
- Chromatin restriction by the nucleosome remodeler Mi-2β and functional interplay with lineage-specific transcription regulators control B-cell differentiation. | Yoshida, T., et al. 2019. Genes Dev. 33: 763-781. PMID: 31123064
- Functional interactions between Mi-2β and AP1 complexes control response and recovery from skin barrier disruption. | Shibata, S., et al. 2020. J Exp Med. 217: PMID: 31834931
- Mi-2β promotes immune evasion in melanoma by activating EZH2 methylation. | Li, C., et al. 2024. Nat Commun. 15: 2163. PMID: 38461299
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Mi2-β Antibody (SW-88) | sc-134386 | 50 µg/0.5 ml | $339.00 |