Mi2-α Antibody (2172C1a): sc-81323
- Mi2-α Antibody (2172C1a) is a mouse monoclonal IgG1 Mi2-α antibody provided at 100 µg/ml
- raised against a recombinant protein corresponding to a region near the C-terminus of Mi2-α of human origin
- recommended for detection of Mi2-α of human origin by WB and IP
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Mi2-α Antibody (2172C1a). This work is in progress.
Mi2-α Antibody (2172C1a) is a mouse monoclonal IgG1 antibody that detects Mi2-alpha protein of human origin by western blotting (WB) and immunoprecipitation (IP). Anti-Mi2-alpha antibody (2172C1a) is available as a non-conjugated format, providing researchers with a reliable tool for studying this important protein. Mi2-alpha protein plays a crucial role in chromatin remodeling, which is essential for the regulation of gene expression. Mi2-alpha protein is a component of the mSin3 corepressor complex, which is involved in the deacetylation of histones, thereby influencing transcriptional silencing. The interaction of Mi2-alpha protein with histone deacetylases, such as HDAC1 and HDAC2, highlights its significance in maintaining chromatin structure and function. By facilitating the removal of acetyl groups from lysine residues on histones, Mi2-alpha protein contributes to the compaction of chromatin, making DNA less accessible to transcription factors and ultimately regulating gene expression. Understanding the function of Mi2-alpha protein and its role in chromatin dynamics is vital for elucidating the mechanisms of transcriptional regulation and the implications of chromatin modifications in various biological processes and diseases.
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Mi2-α Antibody (2172C1a) References:
- The chromatin remodeling factor Mi-2alpha acts as a novel co-activator for human c-Myb. | Saether, T., et al. 2007. J Biol Chem. 282: 13994-4005. PMID: 17344210
- Transcription Factor hDREF Is a Novel SUMO E3 Ligase of Mi2α. | Yamashita, D., et al. 2016. J Biol Chem. 291: 11619-34. PMID: 27068747
- Autoantibodies to Mi-2 alpha and Mi-2 beta in patients with idiopathic inflammatory myopathy. | Richards, M., et al. 2019. Rheumatology (Oxford). 58: 1655-1661. PMID: 30938432
- Antinuclear Antibody (ANA) and Anti-Mi-2-Alpha Positive Dermatomyositis Hinting a Cancer Diagnosis. | Pacheco, M., et al. 2022. Cureus. 14: e21844. PMID: 35291538
- The major dermatomyositis-specific Mi-2 autoantigen is a presumed helicase involved in transcriptional activation. | Seelig, HP., et al. 1995. Arthritis Rheum. 38: 1389-99. PMID: 7575689
- Nucleosome structural changes due to acetylation. | Bauer, WR., et al. 1994. J Mol Biol. 236: 685-90. PMID: 8114086
- A positive role for histone acetylation in transcription factor access to nucleosomal DNA. | Lee, DY., et al. 1993. Cell. 72: 73-84. PMID: 8422685
- Transcriptional silencing in yeast is associated with reduced nucleosome acetylation. | Braunstein, M., et al. 1993. Genes Dev. 7: 592-604. PMID: 8458576
- Repression and activation by multiprotein complexes that alter chromatin structure. | Kingston, RE., et al. 1996. Genes Dev. 10: 905-20. PMID: 8608939
- Histone deacetylases and SAP18, a novel polypeptide, are components of a human Sin3 complex. | Zhang, Y., et al. 1997. Cell. 89: 357-64. PMID: 9150135
- SAP30, a novel protein conserved between human and yeast, is a component of a histone deacetylase complex. | Zhang, Y., et al. 1998. Mol Cell. 1: 1021-31. PMID: 9651585
- The dermatomyositis-specific autoantigen Mi2 is a component of a complex containing histone deacetylase and nucleosome remodeling activities. | Zhang, Y., et al. 1998. Cell. 95: 279-89. PMID: 9790534
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Mi2-α Antibody (2172C1a) | sc-81323 | 100 µg/ml | $333.00 |