MG 624 CAS: 77257-42-2
MF: C22H30NOI
MW: 451.39
An antagonist of neuronal AChR.

MG 624 (CAS 77257-42-2)

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Application: MG 624 is an antagonist of neuronal AChR
CAS Number: 77257-42-2
Molecular Weight: 451.39
Molecular Formula: C22H30NOI
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

MG 624 is a neuronal AChR α7 antagonist. MG 624 inhibits α-Bgtx binding to chick α7 and α4β2 subtypes.


References

Gotti et al (1998) 4-Oxystilbene compounds are selective ligands for neuronal nicotinic abungarotoxin receptors. Br.J.Pharmacol. 124 1197. Maggi et al (1999) Selective effects of a 4-oxystilbene derivative on wild and mutant neuronal chick a7 nicotinic receptor. Br.J.Pharmacol. 126 285.

Physical State :
Solid
Solubility :
Soluble in DMSO (20 mM), and ethanol (10 mM). Insoluble in water.
Storage :
Desiccate at 4° C
Melting Point :
212-213° C
IC50 :
Plasmodium falciparum: IC50 = 0.40 µM; APOBEC503A: IC50 = 2.33 µM (human); APOBEC503G: IC50 = 2.57 µM (human); CTDSP1: IC50 = 20.22 µM (human)
Ki Data :
Inhibits α-Bgtx binding to chick α7 and α4β2 subtypes with Kivalues of 106 nM and 84 µM respectively
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
BS4305000
PubChem CID :
6433339
MDL Number :
MFCD00865233
SMILES :
CC[N+](CC)(CC)CCOC1=CC=C(C=C1)C=CC2=CC=CC=C2.[I-]

Download SDS (MSDS)

Certificate of Analysis

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MG 624 (CAS 77257-42-2)  Product Citations

See how others have used MG 624 (CAS 77257-42-2). Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 28576119  Vicary, GW. et al. 2017. Respir. Res. 18: 115.

Citations 1 to 1 of 1 total
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