Mex3b Antibody (4C4): sc-293407
- Mex3b Antibody (4C4) is a mouse monoclonal IgG2b κ, cited in 1 publications, provided at 100 µg/ml
- raised against amino acids 60-159 of Mex3b of human origin
- recommended for detection of Mex3b of mouse, rat and human origin by WB, IP and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Mex3b Antibody (4C4). This work is in progress.
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Mex3b Antibody (4C4) is a mouse monoclonal IgG2b antibody that detects Mex3b in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Mex3b is a member of the Mex-3 family of RNA-binding phosphoproteins, which are crucial for regulating post-transcriptional events in various biological processes. Mex3b is primarily located in the cytoplasm, where anti-Mex3b antibody (4C4) can detect its significant role in the regulation of mRNA stability and translation, thereby influencing gene expression and cellular function. Mex3b′s ability to shuttle between the nucleus and cytoplasm via the CRM1-dependent export pathway is vital for its function, as this movement allows for the dynamic regulation of target mRNAs in response to cellular signals. Mex3b interacts with specific proteins involved in RNA metabolism, further underscoring its importance in maintaining cellular homeostasis and developmental processes. With unique structural features, including two tandemly repeated KH domains and a C-terminal RING finger motif, Mex3b (4C4) antibody helps researchers study these critical regulatory functions in gene expression and RNA biology.
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Mex3b Antibody (4C4) References:
- The RNA-binding protein Mex3b regulates the spatial organization of the Rap1 pathway. | Le Borgne, M., et al. 2014. Development. 141: 2096-107. PMID: 24803656
- RNA helicase DEAD box protein 5 regulates Polycomb repressive complex 2/Hox transcript antisense intergenic RNA function in hepatitis B virus infection and hepatocarcinogenesis. | Zhang, H., et al. 2016. Hepatology. 64: 1033-48. PMID: 27338022
- The RNA-binding Protein MEX3B Mediates Resistance to Cancer Immunotherapy by Downregulating HLA-A Expression. | Huang, L., et al. 2018. Clin Cancer Res. 24: 3366-3376. PMID: 29496759
- Antigen Presentation Keeps Trending in Immunotherapy Resistance. | Kalbasi, A. and Ribas, A. 2018. Clin Cancer Res. 24: 3239-3241. PMID: 29674509
- The IL-37-Mex3B-Toll-like receptor 3 axis in epithelial cells in patients with eosinophilic chronic rhinosinusitis with nasal polyps. | Liu, JX., et al. 2020. J Allergy Clin Immunol. 145: 160-172. PMID: 31330219
- The RNA-binding protein Mex-3B plays critical roles in the development of steroid-resistant neutrophilic airway inflammation. | Yamazumi, Y., et al. 2019. Biochem Biophys Res Commun. 519: 220-226. PMID: 31493864
- Transcriptome Sequencing Reveals Key Genes in Three Early Phases of Osteogenic, Adipogenic, and Chondrogenic Differentiation of Bone Marrow Mesenchymal Stem Cells in Rats. | Liu, F., et al. 2021. Front Mol Biosci. 8: 782054. PMID: 35223983
- Investigation of the Potential Correlation Between RNA-Binding Proteins in the Evolutionarily Conserved MEX3 Family and Non-small-Cell Lung Cancer. | Zhang, M., et al. 2023. Mol Biotechnol. 65: 1263-1274. PMID: 36507941
- MEX3B inhibits collagen production in eosinophilic nasal polyps by downregulating epithelial cell TGFBR3 mRNA stability. | Liu, JX., et al. 2023. JCI Insight. 8: PMID: 36976645
- Mex3B inhibits DC-STAMP mRNA level and osteoclastogenesis. | Yang, Y., et al. 2022. Cell Insight. 1: 100002. PMID: 37192984
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Mex3b Antibody (4C4) | sc-293407 | 100 µg/ml | $322.00 |