Molecular structure of Mevinolinic acid, monoammonium salt, CAS Number: 77550-67-5
Mevinolinic acid, monoammonium salt (CAS 77550-67-5)
Alternate Names:
Lovastatin ammonium salt
CAS Number:
77550-67-5
Molecular Weight:
439.59
Molecular Formula:
C24H37O6•NH4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Mevinolinic acid, monoammonium salt (CAS 77550-67-5) References
- Supplementation of the cultivation media with B-group vitamins enhances lovastatin biosynthesis by Aspergillus terreus. | Bizukojc, M., et al. 2007. J Biotechnol. 127: 258-68. PMID: 16887228
- Regulation of bile acid synthesis. V. Inhibition of conversion of 7-dehydrocholesterol to cholesterol is associated with down-regulation of cholesterol 7 alpha-hydroxylase activity and inhibition of bile acid synthesis. | Pandak, WM., et al. 1990. J Lipid Res. 31: 2149-58. PMID: 1708805
- Simultaneous biosynthesis of (+)-geodin by a lovastatin-producing fungus Aspergillus terreus. | Bizukojc, M. and Ledakowicz, S. 2007. J Biotechnol. 132: 453-60. PMID: 17689800
- Simultaneous enrichment of deglycosylated ginsenosides and monacolin K in red ginseng by fermentation with Monascus pilosus. | Hong, SY., et al. 2011. Biosci Biotechnol Biochem. 75: 1490-5. PMID: 21821946
- Effect of pH on biosynthesis of lovastatin and other secondary metabolites by Aspergillus terreus ATCC 20542. | Bizukojc, M., et al. 2012. J Biotechnol. 162: 253-61. PMID: 22995742
- Regulation of bile acid synthesis. IV. Interrelationship between cholesterol and bile acid biosynthesis pathways. | Pandak, WM., et al. 1990. J Lipid Res. 31: 79-90. PMID: 2313206
- Induction of secondary metabolism of Aspergillus terreus ATCC 20542 in the batch bioreactor cultures. | Boruta, T. and Bizukojc, M. 2016. Appl Microbiol Biotechnol. 100: 3009-22. PMID: 26603760
- Evaluating the outcomes of submerged co-cultivation: production of lovastatin and other secondary metabolites by Aspergillus terreus in fungal co-cultures. | Boruta, T., et al. 2019. Appl Microbiol Biotechnol. 103: 5593-5605. PMID: 31098686
- Valproic acid teratogenesis and embryonic lipid metabolism. | Clarke, DO. and Brown, NA. 1987. Arch Toxicol Suppl. 11: 143-7. PMID: 3115231
- 3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors. 4. Side chain ester derivatives of mevinolin. | Hoffman, WF., et al. 1986. J Med Chem. 29: 849-52. PMID: 3634830
- Mevalonate supplementation in pregnant rats suppresses the teratogenicity of mevinolinic acid, an inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme a reductase. | Minsker, DH., et al. 1983. Teratology. 28: 449-56. PMID: 6665743
- Mevinolin: a highly potent competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase and a cholesterol-lowering agent. | Alberts, AW., et al. 1980. Proc Natl Acad Sci U S A. 77: 3957-61. PMID: 6933445
- Quantitative analysis of mevinolinic acid in human plasma by high-performance liquid chromatography coupled with negative-ion electrospray tandem mass spectrometry. | Calaf, RE., et al. 1997. Rapid Commun Mass Spectrom. 11: 75-80. PMID: 9050262
Inhibitor of:
HMGCR.Substrate of:
CYP, CYP3A, and PGP.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Mevinolinic acid, monoammonium salt, 100 mg | sc-221939 | 100 mg | $1980.00 |