Molecular structure of Mevastatin (Compactin), CAS Number: 73573-88-3
Mevastatin (Compactin) (CAS 73573-88-3)
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Alternate Names:
Compactin
Application:
Mevastatin (Compactin) is an HMGCR (HMG-CoA reductase) inhibitor
CAS Number:
73573-88-3
Purity:
≥97%
Molecular Weight:
390.5
Molecular Formula:
C23H34O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Mevastatin (Compactin) inhibits HMGCR (HMG-CoA reductase) (Ki for acid form is 1 nM) which in turn inhibits isoprenoid biosynthesis and therefore blocks protein isoprenylation. Mevastatin causes cells to arrest early in the G1 phase. Mevastatin is a close structural analog of lovastatin (sc-200850) and both agents have the same biochemical activities. Mevastatin is inactive in cell-free assays. In cells however, it is hydrolyzed to the active free acid form by intracellular esterases.
Mevastatin (Compactin) (CAS 73573-88-3) References
- Mevastatin inhibits ovarian theca-interstitial cell proliferation and steroidogenesis. | Izquierdo, D., et al. 2004. Fertil Steril. 82 Suppl 3: 1193-7. PMID: 15474095
- Mevastatin reduces cartilage degradation in rabbit experimental osteoarthritis through inhibition of synovial inflammation. | Akasaki, Y., et al. 2009. Osteoarthritis Cartilage. 17: 235-43. PMID: 18672387
- Mevastatin-induced neurite outgrowth of neuroblastoma cells via activation of EGFR. | Evangelopoulos, ME., et al. 2009. J Neurosci Res. 87: 2138-44. PMID: 19224573
- Effects of mevastatin on grafted bone in MRL/MpJ mice. | Sugazaki, M., et al. 2010. Connect Tissue Res. 51: 105-12. PMID: 20109072
- Antileishmanial effect of mevastatin is due to interference with sterol metabolism. | Dinesh, N., et al. 2015. Parasitol Res. 114: 3873-83. PMID: 26183607
- Mevastatin ameliorates sphingosine 1-phosphate-induced COX-2/PGE2-dependent cell migration via FoxO1 and CREB phosphorylation and translocation. | Hsu, CK., et al. 2015. Br J Pharmacol. 172: 5360-76. PMID: 26359950
- Mevastatin blockade of autolysosome maturation stimulates LBH589-induced cell death in triple-negative breast cancer cells. | Lin, Z., et al. 2017. Oncotarget. 8: 17833-17848. PMID: 28147319
- Mevastatin promotes neuronal survival against Aβ-induced neurotoxicity through AMPK activation. | Kornelius, E., et al. 2017. Metab Brain Dis. 32: 1999-2007. PMID: 28840430
- Topical mevastatin promotes wound healing by inhibiting the transcription factor c-Myc via the glucocorticoid receptor and the long non-coding RNA Gas5. | Sawaya, AP., et al. 2018. J Biol Chem. 293: 1439-1449. PMID: 29158265
- Essential role for mevalonate synthesis in DNA replication. | Quesney-Huneeus, V., et al. 1979. Proc Natl Acad Sci U S A. 76: 5056-60. PMID: 291922
- Mevastatin promotes healing by targeting caveolin-1 to restore EGFR signaling. | Sawaya, AP., et al. 2019. JCI Insight. 4: PMID: 31661463
- Mevastatin-Induced AP-1-Dependent HO-1 Expression Suppresses Vascular Cell Adhesion Molecule-1 Expression and Monocyte Adhesion on Human Pulmonary Alveolar Epithelial Cells Challenged with TNF-α. | Yang, CM., et al. 2020. Biomolecules. 10: PMID: 32121588
- The dual role of mevalonate in the cell cycle. | Quesney-Huneeus, V., et al. 1983. J Biol Chem. 258: 378-85. PMID: 6848509
Inhibitor of:
ACOT6, ACSVL2, ALMS1, ARL16, CCDC43, dolichol kinase, Gm1966, GRAMD1B, GTPBP6, HMG-3, HMGCLL1, HMGCR, Lamin A, LAP2, LKLF, LOC100039284, LPAAT-θ, LSR, mHMGCS, NSDHL, PDSS1, PDZ-RhoGEF, PECI, Peroxin 2, PGAP1, plexin-A1, Rab 1B, Rho J, Sarcalumenin, SDPR, SREBP-2, STAG3, TM7SF2, and ZDHHC7.Activator of:
4632434I11Rik, Anthrax LF, C14orf45, Clb1, CMV gH, IFT140, LIMP II, LIN-15A, LOC643862, NSDHL, otoancorin, PGAP1, PIS1, SPPL3, Vac17p, and WDR36.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Mevastatin (Compactin), 10 mg | sc-200853 | 10 mg | $77.00 | |||
Mevastatin (Compactin), 50 mg | sc-200853A | 50 mg | $179.00 |