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Metronidazole (CAS 443-48-1) - chemical structure image
Molecular structure of Metronidazole, CAS Number: 443-48-1
Metronidazole (CAS 443-48-1) - chemical structure image
Molecular structure of Metronidazole, CAS Number: 443-48-1
Molecular structure of Metronidazole, CAS Number: 443-48-1

Metronidazole (CAS 443-48-1)

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Alternate Names:
Metronidazole is also known as 2-Methyl-5-nitroimidazole-1-ethanol.
Application:
Metronidazole is an antibiotic affective against protozoa and anaerobic gram-positive and gram-negative bacteria.
CAS Number:
443-48-1
Purity:
≥99%
Molecular Weight:
171.15
Molecular Formula:
C6H9N3O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Description
Technical Information
Safety Information
SDS & Certificate of Analysis

Metronidazole is a limited spectrum antibiotic that actively deters the growth of protozoa, anaerobic gram-positive, and anaerobic gram-negative bacteria. The first use of Metronidazole was to suppress protozoans such as Entamoeba histolytica, Giardia lamblia and Trichomonas vaginalis. Further studies show that Metronidazole has been used to repress the growth of gram-negative anaerobes belonging to the Bacteroides and Fusobacterium, and gram-positive anaerobes such as peptostreptococcus and Clostridia. The advantages of this antiobiotic is that Metronidazole affects a high percentage of gram-negative bacteria and has greater tissue penetration. Furthermore, the gene hefA codes for the TolC efflux pump in Helicobacter pylori, which is resistant to Metronidazole.


Metronidazole (CAS 443-48-1) References

  1. [Metronidazole].  |  Martinez, V. and Caumes, E. 2001. Ann Dermatol Venereol. 128: 903-9. PMID: 11590342
  2. [Tetracyclines, sulfonamides, and metronidazole].  |  Vicente, D. and Pérez-Trallero, E. 2010. Enferm Infecc Microbiol Clin. 28: 122-30. PMID: 20097452
  3. Enhanced bacterial efflux system is the first step to the development of metronidazole resistance in Helicobacter pylori.  |  Tsugawa, H., et al. 2011. Biochem Biophys Res Commun. 404: 656-60. PMID: 21147064
  4. [Controlling wound odor with metronidazole: a systematic review].  |  Castro, DL. and Santos, VL. 2015. Rev Esc Enferm USP. 49: 858-63. PMID: 26516758
  5. Low efficacy of metronidazole in the eradication of Blastocystis hominis in symptomatic patients: Case series and systematic literature review.  |  Batista, L., et al. 2017. Gastroenterol Hepatol. 40: 381-387. PMID: 28279442
  6. Metronidazole: an update on metabolism, structure-cytotoxicity and resistance mechanisms.  |  Dingsdag, SA. and Hunter, N. 2018. J Antimicrob Chemother. 73: 265-279. PMID: 29077920
  7. Metronidazole stewardship initiative at Christchurch hospitals-achievable with immediate benefits.  |  Gardiner, SJ., et al. 2018. N Z Med J. 131: 53-58. PMID: 29649197
  8. Symposium on antimicrobial agents. Metronidazole.  |  Rosenblatt, JE. and Edson, RS. 1987. Mayo Clin Proc. 62: 1013-7. PMID: 3312851
  9. Effects of metronidazole on mesophilic and thermophilic fermentation: Biodegradation mechanisms, microbial communities, and reversibility.  |  Zhao, W., et al. 2022. Bioresour Technol. 362: 127795. PMID: 35988858
  10. Metronidazole in anaerobic infections: a review of its activity, pharmacokinetics and therapeutic use.  |  Brogden, RN., et al. 1978. Drugs. 16: 387-417. PMID: 363399
  11. Genotoxicity and carcinogenicity of metronidazole.  |  Dobiás, L., et al. 1994. Mutat Res. 317: 177-94. PMID: 7515153
  12. Flagyl (metronidazole hydrochloride).  |  Claussen, DW. 1993. Gastroenterol Nurs. 15: 178-80. PMID: 8443266
  13. Metronidazole. A therapeutic review and update.  |  Freeman, CD., et al. 1997. Drugs. 54: 679-708. PMID: 9360057

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Metronidazole, 5 g

sc-204805
5 g
$47.00

Metronidazole, 25 g

sc-204805A
25 g
$95.00

Hello, what is the half-life of Metronidazole in its powder form when kept at 4C? Thank you

Asked by: l2323
Thank you for your question. Please contact your local distributor or technical service for further assistance.
Answered by: Tech Service 1
Date published: 2021-01-21

Why there is no Metronidazole as oral solution?

Asked by: Steve314
Thank you for your question. Our products are produced and sold exclusively for research purposes and are not specified for use as therapeutics.
Answered by: SCBT Heidelberg Support
Date published: 2018-12-29

Can the metronidazole powder be heated (as part of the water phase while making a cream) or does it lose its efficacy if exposed to heat?

Asked by: RafaNora
Thank you for your question. This chemical, Metronidazole: sc-204805, is intended for research use only and is not intended for Therapeutic or Diagnostic use. It is soluble in water (10 mg/ml at 20C), ethanol (5 mg/ml), methanol, chloroform (<0.5 mg/ml), and DMSO (34 mg/ml at 25C).
Answered by: Technical Support
Date published: 2024-03-14

What is the appearance of the compound?

Asked by: two2igm05
Thank you for your question. The compound, sc-204805, is provided as a white to yellowish crystalline powder. If you have any further questions or concerns, please feel free to contact our Technical Service department by calling 800-457-3801 option 2, emailing scbt@scbt.com, or using the Live Chat function on our website.
Answered by: Tech Service 8
Date published: 2017-01-23

What is the stability of this compound after reconstituting in water?

Asked by: two2igm05
Thank you for your question. Metronidazole, sc-204805, once dissolved should be stored at -80° C and consumed as soon as possible.
Answered by: TechService7
Date published: 2020-02-14
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Rated 1 out of 5 by from Use against protozoal contaminantWe purchased this to treat cell lines contaminated with an unknown amoeba. The product was ineffective against this unknown contaminant.
Date published: 2019-05-17
Rated 4 out of 5 by from I will rate this product a 4 and rate 5I will rate this product a 4 and rate 5 for your logistics, customer service and support.
Date published: 2015-04-20
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Metronidazole is rated 2.5 out of 5 by 2.
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