Metoprolol Acid (CAS 56392-14-4)
QUICK LINKS
Metoprolol Acid, the primary active metabolite of Metoprolol, plays a role in the biochemical pathways influencing cardiovascular dynamics. As a beta-adrenergic receptor antagonist, it exerts its mechanism by selectively binding to β1-adrenergic receptors, predominantly located in cardiac tissues. This selective inhibition is paramount in research focused on understanding the regulation of heart rate, cardiac output, and the modulation of signaling pathways involved in stress responses. Furthermore, its unique pharmacokinetic properties, including its metabolism and excretion, make Metoprolol Acid an invaluable compound in pharmacodynamic studies, enabling scientists to decipher the intricate balance between drug efficacy and metabolic transformation. In the realm of cardiovascular research, Metoprolol Acid serves as a pivotal tool for dissecting the molecular underpinnings of beta-adrenergic receptor functionality and its impact on heart physiology, providing insights into the development of targeted interventions for managing cardiac disorders.
Metoprolol Acid (CAS 56392-14-4) References
- Determination of metoprolol, and its four metabolites in dog plasma. | Fang, J., et al. 2004. J Chromatogr B Analyt Technol Biomed Life Sci. 809: 9-14. PMID: 15282087
- The effects of salvianolic acid B from radix salvia miltiorrhizae on the oral pharmacokinetics of metoprolol and metoprolol acid in rats. | Wan, RZ., et al. 2010. Phytother Res. 24: 846-51. PMID: 19957247
- Rapid chiral separation of atenolol, metoprolol, propranolol and the zwitterionic metoprolol acid using supercritical fluid chromatography-tandem mass spectrometry - Application to wetland microcosms. | Svan, A., et al. 2015. J Chromatogr A. 1409: 251-8. PMID: 26228849
- Fungal treatment of metoprolol and its recalcitrant metabolite metoprolol acid in hospital wastewater: Biotransformation, sorption and ecotoxicological impact. | Jaén-Gil, A., et al. 2019. Water Res. 152: 171-180. PMID: 30669039
- Spatial and Temporal Variability in Attenuation of Polar Organic Micropollutants in an Urban Lowland Stream. | Jaeger, A., et al. 2019. Environ Sci Technol. 53: 2383-2395. PMID: 30754970
- Metoprolol and metoprolol acid degradation in UV/H2O2 treated wastewaters: An integrated screening approach for the identification of hazardous transformation products. | Jaén-Gil, A., et al. 2019. J Hazard Mater. 380: 120851. PMID: 31326839
- Soil influences on uptake and transfer of pharmaceuticals from sewage sludge amended soils to spinach. | Kodešová, R., et al. 2019. J Environ Manage. 250: 109407. PMID: 31472377
- Fate of priority pharmaceuticals and their main metabolites and transformation products in microalgae-based wastewater treatment systems. | García-Galán, MJ., et al. 2020. J Hazard Mater. 390: 121771. PMID: 32127240
- Widespread monitoring of chiral pharmaceuticals in urban rivers reveals stereospecific occurrence and transformation. | Ma, R., et al. 2020. Environ Int. 138: 105657. PMID: 32240890
- Target, suspect and non-target screening analysis from wastewater treatment plant effluents to drinking water using collision cross section values as additional identification criterion. | Hinnenkamp, V., et al. 2022. Anal Bioanal Chem. 414: 425-438. PMID: 33768366
- Biodegradation of metoprolol in oxic and anoxic hyporheic zone sediments: unexpected effects on microbial communities. | Rutere, C., et al. 2021. Appl Microbiol Biotechnol. 105: 6103-6115. PMID: 34338804
- Wastewater surveillance for 168 pharmaceuticals and metabolites in a WWTP: Occurrence, temporal variations and feasibility of metabolic biomarkers for intake estimation. | Duan, L., et al. 2022. Water Res. 216: 118321. PMID: 35339048
- Estimating the prevalence of hypertension in 164 cities in China by wastewater-based epidemiology. | Hou, C., et al. 2023. J Hazard Mater. 443: 130147. PMID: 36283217
- Mechanism of β-blocker biodegradation by wastewater microorganisms. | Yi, M., et al. 2023. J Hazard Mater. 444: 130338. PMID: 36417780
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Metoprolol Acid, 10 mg | sc-211903 | 10 mg | $316.00 |