Molecular structure of Metoprine, CAS Number: 7761-45-7
Metoprine (CAS 7761-45-7)
Alternate Names:
5-(3,4-Dichlorophenyl)-6-methyl-2,4-pyrimidinediamine
Application:
Metoprine is a 2,4-Diaminopyrimidine derivative as antimalarial agent.
CAS Number:
7761-45-7
Purity:
≥97%
Molecular Weight:
269.13
Molecular Formula:
C11H10Cl2N4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Metoprine functions as a histone methyltransferase inhibitor. It acts by inhibiting the enzyme histone methyltransferase, which is responsible for adding methyl groups to histone proteins. By inhibiting this enzyme, Metoprine disrupts the process of histone methylation, which plays a role in regulating gene expression and chromatin structure. This disruption can lead to alterations in gene transcription and ultimately impact cellular processes. Metoprine′s mechanism of action involves interfering with the epigenetic regulation of gene expression at the molecular level, making it useful for studying the role of histone methylation in various biological processes.
Metoprine (CAS 7761-45-7) References
- Metoprine-induced thirst and diuresis in Wistar rats. | Lecklin, A., et al. 1999. Acta Physiol Scand. 165: 325-33. PMID: 10192183
- Antiamnesic effect of metoprine and of selective histamine H(1) receptor agonists in a modified mouse passive avoidance test. | Malmberg-Aiello, P., et al. 2000. Neurosci Lett. 288: 1-4. PMID: 10869801
- Cardiac and regional haemodynamic effects of histamine N-methyltransferase inhibitor metoprine in haemorrhage-shocked rats. | Jochem, J. 2004. Inflamm Res. 53: 316-23. PMID: 15241567
- Effects of (S)-alpha -fluoromethylhistidine and metoprine on locomotor activity and brain histamine content in mice. | Sakai, N., et al. 1992. Life Sci. 51: 397-405. PMID: 1635419
- Blockade of brain histamine metabolism alters methamphetamine-induced expression pattern of stereotypy in mice via histamine H1 receptors. | Kitanaka, J., et al. 2007. Neuroscience. 147: 765-77. PMID: 17570600
- Metoprine induced behavioral modifications and brain regional histamine increase in WAG/Rij and Wistar rats. | Samotaeva, IS., et al. 2012. Epilepsy Res. 101: 148-56. PMID: 22503455
- Lipid-soluble inhibitors of dihydrofolate reductase. I. Kinetics, tissue distribution, and extent of metabolism of pyrimethamine, metoprine, and etoprine in the rat, dog, and man. | Cavallito, JC., et al. 1978. Drug Metab Dispos. 6: 329-37. PMID: 26555
- Synergistic growth inhibition of rat hepatoma cells exposed in vitro to N10-propargyl-5,8-dideazafolate with methotrexate or the lipophilic antifolates trimetrexate or metoprine. | Galivan, J., et al. 1987. Cancer Res. 47: 5256-60. PMID: 2958130
- Metoprine, a histamine N-methyltransferase inhibitor, attenuates methamphetamine-induced hyperlocomotion via activation of histaminergic neurotransmission in mice. | Kitanaka, N., et al. 2021. Pharmacol Biochem Behav. 209: 173257. PMID: 34418452
- Changes in the rat brain histamine content following metoprine and other histamine-methyltransferase (HMT) inhibitors. | Zawilska, J. and Nowak, JZ. 1985. Pol J Pharmacol Pharm. 37: 821-30. PMID: 3832018
- Inhibition of brain histamine metabolism by metoprine. | Hough, LB., et al. 1986. Biochem Pharmacol. 35: 307-10. PMID: 3942601
- Biochemical correlates of responsiveness and collateral sensitivity of some methotrexate-resistant murine tumors to the lipophilic antifolate, metoprine. | Sirotnak, FM., et al. 1982. Cancer Res. 42: 924-8. PMID: 7059991
- Kinetics of metoprine, a lipid-soluble antifolate. | Jones, BR., et al. 1981. Br J Clin Pharmacol. 12: 675-80. PMID: 7332733
- Metoprine, an inhibitor of histamine N-methyltransferase but not catechol-O-methyltransferase, suppresses feeding in sated and in food deprived rats. | Lecklin, A., et al. 1995. Methods Find Exp Clin Pharmacol. 17: 47-52. PMID: 7542717
- The effect of metoprine on glucoprivic feeding induced by 2-deoxy-D-glucose. | Lecklin, A., et al. 1994. Pharmacol Biochem Behav. 49: 853-7. PMID: 7886098
Inhibitor of:
HNMT.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Metoprine, 25 mg | sc-484327 | 25 mg | $359.00 |