Date published: 2026-2-7

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Metopimazine Acid (CAS 18182-00-8)

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Application:
Metopimazine Acid is an acid metabolite of Metopimazine
CAS Number:
18182-00-8
Purity:
≥95%
Molecular Weight:
446.58
Molecular Formula:
C22H26N2O4S2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Metopimazine acid is a compound that functions as a dopamine receptor antagonist in experimention. It acts by blocking the dopamine D2 receptors, thereby inhibiting the binding of dopamine to these receptors. This interference with dopamine signaling can lead to a reduction in the activity of dopaminergic pathways in the central nervous system. By modulating dopamine receptor activity, metopimazine acid can potentially influence various physiological and behavioral processes that are regulated by dopamine, such as motor control, mood, and cognition. At the molecular level, the compound exerts its effect by competitively binding to the dopamine D2 receptors, thereby preventing the activation of downstream signaling pathways. This mechanism of action makes metopimazine acid a relevant function for investigating the role of dopamine receptors in various biological processes and for elucidating the molecular mechanisms underlying dopamine-related functions.


Metopimazine Acid (CAS 18182-00-8) References

  1. Granisetron compared with prednisolone plus metopimazine as anti-emetic prophylaxis during multiple cycles of moderately emetogenic chemotherapy.  |  Sigsgaard, T., et al. 1999. Br J Cancer. 80: 412-8. PMID: 10408847
  2. Evidence of lowest brain penetration of an antiemetic drug, metopimazine, compared to domperidone, metoclopramide and chlorpromazine, using an in vitro model of the blood-brain barrier.  |  Jolliet, P., et al. 2007. Pharmacol Res. 56: 11-7. PMID: 17572097
  3. Effect of iontophoresis and penetration enhancers on transdermal absorption of metopimazine.  |  Bounoure, F., et al. 2008. J Dermatol Sci. 52: 170-7. PMID: 18678472
  4. Fragmentation pathways of metopimazine and its metabolite using ESI-MS(n), HR-MS and H/D exchange.  |  Hubert-Roux, M., et al. 2010. J Mass Spectrom. 45: 1121-9. PMID: 20690157
  5. Initial data on the safety of metopimazine during pregnancy and the risk of major birth defects and pregnancy loss - An observational study using the EFEMERIS database.  |  Vabre, C., et al. 2022. Therapie. 77: 405-412. PMID: 34756562

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Metopimazine Acid, 1 mg

sc-211902
1 mg
$356.00

Metopimazine Acid, 10 mg

sc-211902A
10 mg
$999.00