Date published: 2025-10-15

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Metoclopramide hydrochloride (CAS 7232-21-5)

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Application:
Metoclopramide hydrochloride is a D2DR inhibitor and an HTR3E inhibitor
CAS Number:
7232-21-5
Purity:
≥98%
Molecular Weight:
336.26
Molecular Formula:
C14H22ClN3O2•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Metoclopramide hydrochloride is a D2DR inhibitor and an HTR3E inhibitor. Metoclopramide hydrochloride acts as a dopamine antagonist, meaning that it blocks the action of dopamine. It does this by binding to the dopamine receptors preventing dopamine from binding and activating the receptor. By inhibiting dopamine′s action, it can influence various dopamine-regulated pathways. Additionally, metoclopramide hydrochloride has been observed to have effects on serotonin receptors. Understanding the biochemical properties of metoclopramide hydrochloride is essential for studying the compound′s effects on biochemical pathways.


Metoclopramide hydrochloride (CAS 7232-21-5) References

  1. Newly discovered anti-inflammatory properties of the benzamides and nicotinamides.  |  Pero, RW., et al. 1999. Mol Cell Biochem. 193: 119-25. PMID: 10331648
  2. Effect of different prokinetic agents and a novel enterokinetic agent on postoperative ileus in rats.  |  De Winter, BY., et al. 1999. Gut. 45: 713-8. PMID: 10517907
  3. Metoclopramide-associated tardive dyskinesia. An analysis of 67 cases.  |  Sewell, DD. and Jeste, DV. 1992. Arch Fam Med. 1: 271-8. PMID: 1341603
  4. Gastroretentive drug delivery system of metoclopramide hydrochloride: formulation and in vitro evaluation.  |  Singh, S., et al. 2007. Curr Drug Deliv. 4: 269-75. PMID: 17979646
  5. Biowaiver monographs for immediate release solid oral dosage forms: metoclopramide hydrochloride.  |  Stosik, AG., et al. 2008. J Pharm Sci. 97: 3700-8. PMID: 18271037
  6. Compressed matrix dual-component vaginal drug delivery system containing metoclopramide hydrochloride.  |  Patel, GM. and Patel, MM. 2009. Acta Pharm. 59: 273-88. PMID: 19819824
  7. In situ gels of Metoclopramide Hydrochloride for intranasal delivery: in vitro evaluation and in vivo pharmacokinetic study in rabbits.  |  Mahajan, HS. and Gattani, S. 2010. Drug Deliv. 17: 19-27. PMID: 19958151
  8. Spectrofluorimetric assessment of metoclopramide hydrochloride using terbium doped in PMMA matrix optical sensor.  |  Attia, MS., et al. 2011. J Fluoresc. 21: 739-45. PMID: 21052809
  9. Formulation and evaluation of bilayer tablets of metoclopramide hydrochloride and diclofenac sodium.  |  Gattani, SG., et al. 2012. PDA J Pharm Sci Technol. 66: 151-60. PMID: 22492600
  10. Zero-order release profile of metoclopramide hydrochloride sublingual tablet formulation.  |  Latif, R. 2013. Pharm Dev Technol. 18: 1372-8. PMID: 22963706
  11. Metoclopramide-induced parkinsonism.  |  Sethi, KD., et al. 1989. South Med J. 82: 1581-2. PMID: 2595431
  12. Validation and application of high performance liquid chromatographic method for the estimation of metoclopramide hydrochloride in plasma.  |  Khan, A., et al. 2017. Pak J Pharm Sci. 30: 143-147. PMID: 28603124
  13. Polymorphism in metoclopramide hydrochloride and metoclopramide.  |  Mitchell, AG. 1985. J Pharm Pharmacol. 37: 601-4. PMID: 2867177
  14. Evaluation of the effectiveness of preoperative administration of maropitant citrate and metoclopramide hydrochloride in preventing postoperative clinical gastroesophageal reflux in dogs.  |  Jones, CT. and Fransson, BA. 2019. J Am Vet Med Assoc. 255: 437-445. PMID: 31355727

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Metoclopramide hydrochloride, 10 g

sc-253046
10 g
$56.00

Metoclopramide hydrochloride, 25 g

sc-253046A
25 g
$123.00